Overexpression of p53 protein is an independent prognostic indicator in human endometrial carcinoma

R. Soong, S. Knowles, K.E. Williams, I.G. Hammond, S.J. Wysocki, Barry Iacopetta

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

The important role of the p53 gene in tumour progression and cellular response to DNA damage has prompted investigation of the clinical significance of alterations to this gene. We examined both p53 overexpression and mutation of the gene in endometrial carcinoma in order to evaluate the prognostic significance of these changes. Of 122 endometrial carcinomas, 33 (27%) showed overexpression of p53 in the nucleus and 66 (54%) in the cytoplasm. Mutation in the p53 gene was found in 16 (13%) cases but showed no significant association with patient survival. Nuclear p53 overexpression was associated with poor survival (48% vs 80% alive in negative tumours 5 years post operatively, P
Original languageEnglish
Pages (from-to)562-567
JournalBritish Journal of Cancer
Volume74
DOIs
Publication statusPublished - 1996

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