Outcomes following tympanoplasty surgery using porcine derived small intestinal submucosa (SIS)

Objective: To determine the outcomes of tympanoplasty surgery using porcine derived small intestinal submucosa (SIS). Study Design: Retrospective audit. Setting: Hospital. Patients: 35 adult and paediatric patients who received a SIS graft as part of tympanoplasty surgery were retrospectively reviewed. Intervention: Patients underwent either simple tympanoplasty (n=26) or complex tympanoplasty as part of a concurrent otological procedure such as atticotomy and mastoidectomy. Main outcome measure: Tympanic membrane closure rate and change in four frequency mean air bone gap (ABG). Results: 31 patients had a follow up period of longer than 2 months. Closure was obtained in 22 patients (71%). The mean ABG in the simple tympanoplasty group improved from 20.7dB HL to 12.3db HL. The corresponding improvement in the complex tympanoplasty group was from 22.3dB to 12 db HL (std dev 9). Conclusion: Tympanoplasty surgery with SIS is a viable option for patients where autologous graft is not available or in order to minimise donor site morbidity.