TY - JOUR
T1 - Outcome measures for technique survival reported in peritoneal dialysis
T2 - A systematic review
AU - Elphick, Emma
AU - Holmes, Matthew
AU - Tabinor, Matthew
AU - Cho, Yeoungjee
AU - Nguyen, Thu
AU - Harris, Tess
AU - Wang, Angela Yee Moon
AU - Jain, Arsh K.
AU - Ponce, Daniela
AU - Chow, Josephine S.F.
AU - Nadeau-Fredette, Annie Claire
AU - Liew, Adrian
AU - Boudville, Neil
AU - Tong, Allison
AU - Johnson, David W.
AU - Davies, Simon J.
AU - Perl, Jeffrey
AU - Manera, Karine E.
AU - Lambie, Mark
PY - 2022/5
Y1 - 2022/5
N2 - Background: Peritoneal dialysis (PD) technique survival is an important outcome for patients, caregivers and health professionals, however, the definition and measures used for technique survival vary. We aimed to assess the scope and consistency of definitions and measures used for technique survival in studies of patients receiving PD. Method: MEDLINE, EMBASE and CENTRAL databases were searched for randomised controlled studies (RCTs) conducted in patients receiving PD reporting technique survival as an outcome between database inception and December 2019. The definition and measures used were extracted and independently assessed by two reviewers. Results: We included 25 RCTs with a total of 3645 participants (41–371 per trial) and follow up ranging from 6 weeks to 4 years. Terminology used included ‘technique survival’ (10 studies), ‘transfer to haemodialysis (HD)’ (8 studies) and ‘technique failure’ (7 studies) with 17 different definitions. In seven studies, it was unclear whether the definition included transfer to HD, death or transplantation and eight studies reported ‘transfer to HD’ without further definition regarding duration or other events. Of those remaining, five studies included death in their definition of a technique event, whereas death was censored in the other five. The duration of HD necessary to qualify as an event was reported in only four (16%) studies. Of the 14 studies reporting causes of an event, all used a different list of causes. Conclusion: There is substantial heterogeneity in how PD technique survival is defined and measured, likely contributing to considerable variability in reported rates. Standardised measures for reporting technique survival in PD studies are required to improve comparability.
AB - Background: Peritoneal dialysis (PD) technique survival is an important outcome for patients, caregivers and health professionals, however, the definition and measures used for technique survival vary. We aimed to assess the scope and consistency of definitions and measures used for technique survival in studies of patients receiving PD. Method: MEDLINE, EMBASE and CENTRAL databases were searched for randomised controlled studies (RCTs) conducted in patients receiving PD reporting technique survival as an outcome between database inception and December 2019. The definition and measures used were extracted and independently assessed by two reviewers. Results: We included 25 RCTs with a total of 3645 participants (41–371 per trial) and follow up ranging from 6 weeks to 4 years. Terminology used included ‘technique survival’ (10 studies), ‘transfer to haemodialysis (HD)’ (8 studies) and ‘technique failure’ (7 studies) with 17 different definitions. In seven studies, it was unclear whether the definition included transfer to HD, death or transplantation and eight studies reported ‘transfer to HD’ without further definition regarding duration or other events. Of those remaining, five studies included death in their definition of a technique event, whereas death was censored in the other five. The duration of HD necessary to qualify as an event was reported in only four (16%) studies. Of the 14 studies reporting causes of an event, all used a different list of causes. Conclusion: There is substantial heterogeneity in how PD technique survival is defined and measured, likely contributing to considerable variability in reported rates. Standardised measures for reporting technique survival in PD studies are required to improve comparability.
KW - Peritoneal dialysis
KW - systematic review
KW - technique survival
KW - transfer to haemodialysis
UR - http://www.scopus.com/inward/record.url?scp=85104830414&partnerID=8YFLogxK
U2 - 10.1177/0896860821989874
DO - 10.1177/0896860821989874
M3 - Review article
C2 - 33882725
AN - SCOPUS:85104830414
SN - 0896-8608
VL - 42
SP - 279
EP - 287
JO - Peritoneal Dialysis International
JF - Peritoneal Dialysis International
IS - 3
ER -