Osteoporosis in patients with dementia is associated with high morbidity and mortality Findings from a single orthogeriatric unit

Noreen Mughal, Andrisha J. Inderjeeth, Charles A. Inderjeeth

Research output: Contribution to journalArticle

Abstract

Background and objectives

Osteoporosis and dementia are common and associated with a high healthcare burden. The aim of this paper was to assess the impact of dementia on treatment, morbidity and mortality in osteoporosis.

Methods

Data were collected on 502 prospective orthogeriatric admissions for fracture. Fisher's exact chi-square was used to compare treatment stratified by dementia status.

Results

Of the 502 patients, 281 (56%) had osteoporosis, 226 (45%) had dementia, and 156 (31%) had dementia and osteoporosis diagnosed before they sustained fractures. Patients with dementia were more likely to have osteoporosis but less likely to be receiving treatment. Although there was a significant improvement in discharge versus admission rates of osteoporosis treatment, those with dementia were less likely to be treated with antiresorptive therapy (36%, compared with 59%, P <0.001) or combined therapy (32%, compared with 56%, P <0.001) and had double the 90-day mortality (17.3%, compared with 9.6%) and six times the 30-day mortality (6.4%, compared with 1.6%).

Discussion

Patients with dementia and osteoporosis have a higher risk of recurrent fractures and mortality. Prevention may be the key strategy.

Original languageEnglish
Pages (from-to)53-58
Number of pages6
JournalAustralian journal of general practice
Volume48
Issue number1-2
Publication statusPublished - Jan 2019

Cite this

@article{5ffe9c19c626460d913d6573eae203f0,
title = "Osteoporosis in patients with dementia is associated with high morbidity and mortality Findings from a single orthogeriatric unit",
abstract = "Background and objectivesOsteoporosis and dementia are common and associated with a high healthcare burden. The aim of this paper was to assess the impact of dementia on treatment, morbidity and mortality in osteoporosis.MethodsData were collected on 502 prospective orthogeriatric admissions for fracture. Fisher's exact chi-square was used to compare treatment stratified by dementia status.ResultsOf the 502 patients, 281 (56{\%}) had osteoporosis, 226 (45{\%}) had dementia, and 156 (31{\%}) had dementia and osteoporosis diagnosed before they sustained fractures. Patients with dementia were more likely to have osteoporosis but less likely to be receiving treatment. Although there was a significant improvement in discharge versus admission rates of osteoporosis treatment, those with dementia were less likely to be treated with antiresorptive therapy (36{\%}, compared with 59{\%}, P <0.001) or combined therapy (32{\%}, compared with 56{\%}, P <0.001) and had double the 90-day mortality (17.3{\%}, compared with 9.6{\%}) and six times the 30-day mortality (6.4{\%}, compared with 1.6{\%}).DiscussionPatients with dementia and osteoporosis have a higher risk of recurrent fractures and mortality. Prevention may be the key strategy.",
keywords = "FRACTURE, RISK",
author = "Noreen Mughal and Inderjeeth, {Andrisha J.} and Inderjeeth, {Charles A.}",
year = "2019",
month = "1",
language = "English",
volume = "48",
pages = "53--58",
journal = "Australian journal of general practice",
issn = "2208-794X",
publisher = "The Royal Australian College of General Practitioners",
number = "1-2",

}

Osteoporosis in patients with dementia is associated with high morbidity and mortality Findings from a single orthogeriatric unit. / Mughal, Noreen; Inderjeeth, Andrisha J.; Inderjeeth, Charles A.

In: Australian journal of general practice, Vol. 48, No. 1-2, 01.2019, p. 53-58.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Osteoporosis in patients with dementia is associated with high morbidity and mortality Findings from a single orthogeriatric unit

AU - Mughal, Noreen

AU - Inderjeeth, Andrisha J.

AU - Inderjeeth, Charles A.

PY - 2019/1

Y1 - 2019/1

N2 - Background and objectivesOsteoporosis and dementia are common and associated with a high healthcare burden. The aim of this paper was to assess the impact of dementia on treatment, morbidity and mortality in osteoporosis.MethodsData were collected on 502 prospective orthogeriatric admissions for fracture. Fisher's exact chi-square was used to compare treatment stratified by dementia status.ResultsOf the 502 patients, 281 (56%) had osteoporosis, 226 (45%) had dementia, and 156 (31%) had dementia and osteoporosis diagnosed before they sustained fractures. Patients with dementia were more likely to have osteoporosis but less likely to be receiving treatment. Although there was a significant improvement in discharge versus admission rates of osteoporosis treatment, those with dementia were less likely to be treated with antiresorptive therapy (36%, compared with 59%, P <0.001) or combined therapy (32%, compared with 56%, P <0.001) and had double the 90-day mortality (17.3%, compared with 9.6%) and six times the 30-day mortality (6.4%, compared with 1.6%).DiscussionPatients with dementia and osteoporosis have a higher risk of recurrent fractures and mortality. Prevention may be the key strategy.

AB - Background and objectivesOsteoporosis and dementia are common and associated with a high healthcare burden. The aim of this paper was to assess the impact of dementia on treatment, morbidity and mortality in osteoporosis.MethodsData were collected on 502 prospective orthogeriatric admissions for fracture. Fisher's exact chi-square was used to compare treatment stratified by dementia status.ResultsOf the 502 patients, 281 (56%) had osteoporosis, 226 (45%) had dementia, and 156 (31%) had dementia and osteoporosis diagnosed before they sustained fractures. Patients with dementia were more likely to have osteoporosis but less likely to be receiving treatment. Although there was a significant improvement in discharge versus admission rates of osteoporosis treatment, those with dementia were less likely to be treated with antiresorptive therapy (36%, compared with 59%, P <0.001) or combined therapy (32%, compared with 56%, P <0.001) and had double the 90-day mortality (17.3%, compared with 9.6%) and six times the 30-day mortality (6.4%, compared with 1.6%).DiscussionPatients with dementia and osteoporosis have a higher risk of recurrent fractures and mortality. Prevention may be the key strategy.

KW - FRACTURE

KW - RISK

M3 - Article

VL - 48

SP - 53

EP - 58

JO - Australian journal of general practice

JF - Australian journal of general practice

SN - 2208-794X

IS - 1-2

ER -