Osteohematology: To be or Notch to be

Emel Rothzerg, Wendy N. Erber, Christopher L.M.H. Gibbons, David Wood, Jiake Xu

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Osteohematology is an emerging research field that studies the crosstalk between hematopoietic and bone stromal cells, to elucidate the mechanisms of hematological and skeletal malignancies and diseases. The Notch is an evolutionary conserved developmental signaling pathway, with critical roles in embryonic development by controlling cell proliferation and differentiation. However, the Notch pathway is also critically involved in cancer initiation and progression, such as osteosarcoma, leukemia, and multiple myeloma. The Notch-mediated malignant cells dysregulate bone and bone marrow cells in the tumour microenvironment, resulting in disorders ranging from osteoporosis to bone marrow dysfunction. To date, the complex interplay of Notch signaling molecules in hematopoietic and bone stromal cells is still poorly understood. In this mini-review, we summarize the crosstalk between cells in bone and bone marrow and their influence under the Notch signaling pathway in physiological conditions and in tumour microenvironment.

Original languageEnglish
Pages (from-to)1478-1491
Number of pages14
JournalJournal of Cellular Physiology
Volume238
Issue number7
DOIs
Publication statusPublished - Jul 2023

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