TY - JOUR
T1 - Oral potentially malignant disorders
T2 - Risk of progression to malignancy
AU - Speight, Paul M.
AU - Khurram, Syed Ali
AU - Kujan, Omar
PY - 2018/6
Y1 - 2018/6
N2 - Oral potentially malignant disorders (OPMDs) have a statistically increased risk of progressing to cancer, but the risk varies according to a range of patient- or lesion-related factors. It is difficult to predict the risk of progression in any individual patient, and the clinician must make a judgment based on assessment of each case. The most commonly encountered OPMD is leukoplakia, but others, including lichen planus, oral submucous fibrosis, and erythroplakia, may also be seen. Factors associated with an increased risk of malignant transformation include sex; site and type of lesion; habits, such as smoking and alcohol consumption; and the presence of epithelial dysplasia on histologic examination. In this review, we attempt to identify important risk factors and present a simple algorithm that can be used as a guide for risk assessment at each stage of the clinical evaluation of a patient.
AB - Oral potentially malignant disorders (OPMDs) have a statistically increased risk of progressing to cancer, but the risk varies according to a range of patient- or lesion-related factors. It is difficult to predict the risk of progression in any individual patient, and the clinician must make a judgment based on assessment of each case. The most commonly encountered OPMD is leukoplakia, but others, including lichen planus, oral submucous fibrosis, and erythroplakia, may also be seen. Factors associated with an increased risk of malignant transformation include sex; site and type of lesion; habits, such as smoking and alcohol consumption; and the presence of epithelial dysplasia on histologic examination. In this review, we attempt to identify important risk factors and present a simple algorithm that can be used as a guide for risk assessment at each stage of the clinical evaluation of a patient.
UR - http://www.scopus.com/inward/record.url?scp=85041005416&partnerID=8YFLogxK
U2 - 10.1016/j.oooo.2017.12.011
DO - 10.1016/j.oooo.2017.12.011
M3 - Article
C2 - 29396319
AN - SCOPUS:85041005416
VL - 125
SP - 612
EP - 627
JO - Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics
JF - Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics
SN - 1079-2104
IS - 6
ER -