Oral Mucositis

Research output: Chapter in Book/Conference paperChapterpeer-review


Oral mucositis is a common complication of non-surgical cancer therapy. It is associated with significant pain, impaired oral function, malnutrition, increased risk of infection and of cancer treatment interruptions. Oxidative stress and reactive oxygen species generated by chemotherapeutic agents or radiation therapy initiate complex pathways culminating in tissue damage characteristic of mucositis. Oral mucositis varies between individuals, depending on treatment regimens and individual patient factors. Clinical presentation can vary from erythematous, atrophic lesions through to ulcerations which penetrate the submucosa. Lesions typically heal within 2–4 weeks after the last dose of chemo- or radiation therapy. Oral mucositis may be complicated by neutropenia and predispose to bacteremia, septicemia, and fungemia, which may be life threatening. Evidence-based guidelines developed by the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology partnership outline the management of oral mucositis, which may be approached from a preventative or a treatment perspective.
Original languageEnglish
Title of host publicationOral Medicine - A Clinical Guide
EditorsRamesh Balasubramaniam, Sue-Ching Yeoh, Tami Yap, S.R. Prabhu
Place of PublicationSwitzerland
ISBN (Electronic)9783031367977
ISBN (Print)9783031367960
Publication statusPublished - Feb 2024


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