Oral health experiences of individuals with Rett syndrome: A retrospective study

Y. Y.L. Lai, K. Wong, N. M. King, J. Downs, H. Leonard

Research output: Contribution to journalArticle

Abstract

Background: There is relatively little literature on the oral health experiences of individuals with Rett syndrome. This study described the incidence of dental extractions and restorations in a population-based cohort, according to a range of demographic and clinical factors. The association between bruxism and age was also investigated. Methods: Existing questionnaire data in the population-based Australian Rett Syndrome Database for the years 2004, 2006, 2009 or 2011 on genetically confirmed female cases (n=242) were analysed. Results: The incidence rate of restorations and extractions were 6.8 per 100 person years (py) and 9.3 per 100 py respectively. The incidence of extractions decreased with increasing levels of income. Compared to those with a C-terminal mutation, the incidence rate of extraction was higher for those with large deletions (Incidence Rate Ratio (IRR) 4.93; 95% CI 1.46-16.7, p=0.01). There was a 5% decrease in the risk of frequent bruxism for every one-year increase in age (Risk Ratio 0.95; 95% CI 0.94-0.97). Conclusions: Social advantage may provide some protection for dental health in individuals with Rett syndrome. Those with more severe genotypes seemed to have poorer oral health outcomes.

Original languageEnglish
Article number195
JournalBMC Oral Health
Volume18
Issue number1
DOIs
Publication statusPublished - 29 Nov 2018

Fingerprint

Rett Syndrome
Oral Health
Retrospective Studies
Bruxism
Incidence
Tooth Extraction
Mutation Rate
Population
Tooth
Cohort Studies
Odds Ratio
Genotype
Demography
Databases
Health

Cite this

@article{9ef4ad1288394727b9c3df9ee5328d47,
title = "Oral health experiences of individuals with Rett syndrome: A retrospective study",
abstract = "Background: There is relatively little literature on the oral health experiences of individuals with Rett syndrome. This study described the incidence of dental extractions and restorations in a population-based cohort, according to a range of demographic and clinical factors. The association between bruxism and age was also investigated. Methods: Existing questionnaire data in the population-based Australian Rett Syndrome Database for the years 2004, 2006, 2009 or 2011 on genetically confirmed female cases (n=242) were analysed. Results: The incidence rate of restorations and extractions were 6.8 per 100 person years (py) and 9.3 per 100 py respectively. The incidence of extractions decreased with increasing levels of income. Compared to those with a C-terminal mutation, the incidence rate of extraction was higher for those with large deletions (Incidence Rate Ratio (IRR) 4.93; 95{\%} CI 1.46-16.7, p=0.01). There was a 5{\%} decrease in the risk of frequent bruxism for every one-year increase in age (Risk Ratio 0.95; 95{\%} CI 0.94-0.97). Conclusions: Social advantage may provide some protection for dental health in individuals with Rett syndrome. Those with more severe genotypes seemed to have poorer oral health outcomes.",
keywords = "Dental manifestation, Developmental disability, MECP2, Oral health experience, Rare disorder, Rett syndrome",
author = "Lai, {Y. Y.L.} and K. Wong and King, {N. M.} and J. Downs and H. Leonard",
year = "2018",
month = "11",
day = "29",
doi = "10.1186/s12903-018-0651-y",
language = "English",
volume = "18",
journal = "BMC Oral Health",
issn = "1472-6831",
publisher = "BioMed Central",
number = "1",

}

Oral health experiences of individuals with Rett syndrome : A retrospective study. / Lai, Y. Y.L.; Wong, K.; King, N. M.; Downs, J.; Leonard, H.

In: BMC Oral Health, Vol. 18, No. 1, 195, 29.11.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Oral health experiences of individuals with Rett syndrome

T2 - A retrospective study

AU - Lai, Y. Y.L.

AU - Wong, K.

AU - King, N. M.

AU - Downs, J.

AU - Leonard, H.

PY - 2018/11/29

Y1 - 2018/11/29

N2 - Background: There is relatively little literature on the oral health experiences of individuals with Rett syndrome. This study described the incidence of dental extractions and restorations in a population-based cohort, according to a range of demographic and clinical factors. The association between bruxism and age was also investigated. Methods: Existing questionnaire data in the population-based Australian Rett Syndrome Database for the years 2004, 2006, 2009 or 2011 on genetically confirmed female cases (n=242) were analysed. Results: The incidence rate of restorations and extractions were 6.8 per 100 person years (py) and 9.3 per 100 py respectively. The incidence of extractions decreased with increasing levels of income. Compared to those with a C-terminal mutation, the incidence rate of extraction was higher for those with large deletions (Incidence Rate Ratio (IRR) 4.93; 95% CI 1.46-16.7, p=0.01). There was a 5% decrease in the risk of frequent bruxism for every one-year increase in age (Risk Ratio 0.95; 95% CI 0.94-0.97). Conclusions: Social advantage may provide some protection for dental health in individuals with Rett syndrome. Those with more severe genotypes seemed to have poorer oral health outcomes.

AB - Background: There is relatively little literature on the oral health experiences of individuals with Rett syndrome. This study described the incidence of dental extractions and restorations in a population-based cohort, according to a range of demographic and clinical factors. The association between bruxism and age was also investigated. Methods: Existing questionnaire data in the population-based Australian Rett Syndrome Database for the years 2004, 2006, 2009 or 2011 on genetically confirmed female cases (n=242) were analysed. Results: The incidence rate of restorations and extractions were 6.8 per 100 person years (py) and 9.3 per 100 py respectively. The incidence of extractions decreased with increasing levels of income. Compared to those with a C-terminal mutation, the incidence rate of extraction was higher for those with large deletions (Incidence Rate Ratio (IRR) 4.93; 95% CI 1.46-16.7, p=0.01). There was a 5% decrease in the risk of frequent bruxism for every one-year increase in age (Risk Ratio 0.95; 95% CI 0.94-0.97). Conclusions: Social advantage may provide some protection for dental health in individuals with Rett syndrome. Those with more severe genotypes seemed to have poorer oral health outcomes.

KW - Dental manifestation

KW - Developmental disability

KW - MECP2

KW - Oral health experience

KW - Rare disorder

KW - Rett syndrome

UR - http://www.scopus.com/inward/record.url?scp=85057568061&partnerID=8YFLogxK

U2 - 10.1186/s12903-018-0651-y

DO - 10.1186/s12903-018-0651-y

M3 - Article

VL - 18

JO - BMC Oral Health

JF - BMC Oral Health

SN - 1472-6831

IS - 1

M1 - 195

ER -