Oral contraception does not alter typical post-exercise interleukin-6 and hepcidin levels in females

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Abstract

© 2013 Sports Medicine Australia. Objectives: The post-exercise interleukin-6 (IL-6) and hepcidin response was investigated during the hormone-deplete and hormone-replete phases of an estradiol and progestogen regulated oral contraceptive cycle (OCC). Design: Counterbalanced, repeated measures cross-over study. Methods: Ten active female monophasic oral contraceptive pill (OCP) users completed two 40min treadmill running trials at 75% of their pre-determined peak oxygen uptake velocity (vVO2peak). These trials were randomly performed in two specific phases of the OCC: (a) Day 2-4, representing a hormone-free withdrawal period (D-0); (b) Day 12-14, representing the end of the first week of active hormone therapy (D+7). Venous blood samples were drawn pre-, post- and 3h post-exercise. Results: In both trials, serum IL-6 was significantly elevated (p
Original languageEnglish
Pages (from-to)8-12
JournalJournal of Science and Medicine in Sport
Volume18
Issue number1
DOIs
Publication statusPublished - 2015

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Hepcidins
Contraception
Interleukin-6
Oral Contraceptives
Hormones
Sports Medicine
Progestins
Cross-Over Studies
Estradiol
Oxygen
Serum

Cite this

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title = "Oral contraception does not alter typical post-exercise interleukin-6 and hepcidin levels in females",
abstract = "{\circledC} 2013 Sports Medicine Australia. Objectives: The post-exercise interleukin-6 (IL-6) and hepcidin response was investigated during the hormone-deplete and hormone-replete phases of an estradiol and progestogen regulated oral contraceptive cycle (OCC). Design: Counterbalanced, repeated measures cross-over study. Methods: Ten active female monophasic oral contraceptive pill (OCP) users completed two 40min treadmill running trials at 75{\%} of their pre-determined peak oxygen uptake velocity (vVO2peak). These trials were randomly performed in two specific phases of the OCC: (a) Day 2-4, representing a hormone-free withdrawal period (D-0); (b) Day 12-14, representing the end of the first week of active hormone therapy (D+7). Venous blood samples were drawn pre-, post- and 3h post-exercise. Results: In both trials, serum IL-6 was significantly elevated (p",
author = "Marc Sim and Brian Dawson and Grant Landers and D.W. Swinkels and H. Tjalsma and Bu Yeap and Debbie Trinder and Peter Peeling",
year = "2015",
doi = "10.1016/j.jsams.2013.11.008",
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TY - JOUR

T1 - Oral contraception does not alter typical post-exercise interleukin-6 and hepcidin levels in females

AU - Sim, Marc

AU - Dawson, Brian

AU - Landers, Grant

AU - Swinkels, D.W.

AU - Tjalsma, H.

AU - Yeap, Bu

AU - Trinder, Debbie

AU - Peeling, Peter

PY - 2015

Y1 - 2015

N2 - © 2013 Sports Medicine Australia. Objectives: The post-exercise interleukin-6 (IL-6) and hepcidin response was investigated during the hormone-deplete and hormone-replete phases of an estradiol and progestogen regulated oral contraceptive cycle (OCC). Design: Counterbalanced, repeated measures cross-over study. Methods: Ten active female monophasic oral contraceptive pill (OCP) users completed two 40min treadmill running trials at 75% of their pre-determined peak oxygen uptake velocity (vVO2peak). These trials were randomly performed in two specific phases of the OCC: (a) Day 2-4, representing a hormone-free withdrawal period (D-0); (b) Day 12-14, representing the end of the first week of active hormone therapy (D+7). Venous blood samples were drawn pre-, post- and 3h post-exercise. Results: In both trials, serum IL-6 was significantly elevated (p

AB - © 2013 Sports Medicine Australia. Objectives: The post-exercise interleukin-6 (IL-6) and hepcidin response was investigated during the hormone-deplete and hormone-replete phases of an estradiol and progestogen regulated oral contraceptive cycle (OCC). Design: Counterbalanced, repeated measures cross-over study. Methods: Ten active female monophasic oral contraceptive pill (OCP) users completed two 40min treadmill running trials at 75% of their pre-determined peak oxygen uptake velocity (vVO2peak). These trials were randomly performed in two specific phases of the OCC: (a) Day 2-4, representing a hormone-free withdrawal period (D-0); (b) Day 12-14, representing the end of the first week of active hormone therapy (D+7). Venous blood samples were drawn pre-, post- and 3h post-exercise. Results: In both trials, serum IL-6 was significantly elevated (p

U2 - 10.1016/j.jsams.2013.11.008

DO - 10.1016/j.jsams.2013.11.008

M3 - Article

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JO - Journal of Science and Medicine in Sport

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