Oral Carcinogenesis and Malignant Transformation

Camile S. Farah, Kate Shearston, Amanda Phoon Nguyen, Omar Kujan

Research output: Chapter in Book/Conference paperChapterpeer-review

13 Citations (Web of Science)


Cancer of the oral cavity and oropharynx is a significant health burden, with over 300,000 new cases diagnosed annually [1]. Oral squamous cell carcinoma (OSCC) constitutes 95% of these malignancies and is mostly preceded by lesions termed oral potentially malignant disorders (OPMDs) that have a high tendency for malignant transformation [2]. Despite advances in diagnosis and treatment modalities, the survival rate of OSCC has not changed significantly in the last five decades [3]. The poor prognosis of oral cancer can largely be attributed to its frequent diagnosis at an advanced stage [4]. Understanding the process and natural history of oral carcinogenesis has the capacity to improve the clinical outcomes of patients with OSCC through early detection and effective OPMD management. This chapter discusses the most recent concepts and knowledge on oral carcinogenesis and malignant transformation of OPMDs.
Original languageEnglish
Title of host publicationPremalignant Conditions of the Oral Cavity
EditorsPeter A. Brennan, Tom Aldridge, Raghav C. Dwivedi
Place of PublicationSingapore
ISBN (Electronic)978-981-13-2931-9
ISBN (Print)978-981-13-2930-2
Publication statusPublished - 2018

Publication series

NameHead and Neck Cancer Clinics
ISSN (Print)2364-4060
ISSN (Electronic)2364-4079


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