Optimizing cholesterol treatment in patients with muscle complaints

Robert S. Rosenson; Steven Baker; Maciej Banach; Kenneth M. Borow; Lynne T. Braun; Eric Bruckert; Liam R. Brunham; Alberico L. Catapano; Marshall B. Elam; G. B. John Mancini; Patrick M. Moriarty; Pamela B. Morris; Paul Muntner; Kausik K. Ray; Erik S. Stroes; Beth A. Taylor; Valerie H. Taylor; Gerald F. Watts; Paul D. Thompson

doi:10.1016/j.jacc.2017.07.752

Optimizing cholesterol treatment in patients with muscle complaints

Robert S. Rosenson, Steven Baker, Maciej Banach, Kenneth M. Borow, Lynne T. Braun, Eric Bruckert, Liam R. Brunham, Alberico L. Catapano, Marshall B. Elam, G. B. John Mancini, Patrick M. Moriarty, Pamela B. Morris, Paul Muntner, Kausik K. Ray, Erik S. Stroes, Beth A. Taylor, Valerie H. Taylor, Gerald F. Watts, Paul D. Thompson

UWA Medical School

Research output: Contribution to journal › Review article › peer-review

153 Citations (Scopus)

Abstract

Statins are highly effective for preventing cardiovascular events by reducing low-density lipoprotein cholesterol (LDL-C). However, many patients taking statins report muscle-related symptoms that prevent the use of guideline recommended doses. Patients with reported intolerance to statins have a high risk of cardiovascular events. Clinical strategies that optimize cardiovascular risk reduction through LDL-C lowering need to be applied in patients experiencing intolerable side effects that they attribute to statins. In this paper, the authors review definitions of statin intolerance, propose algorithms to better define statin intolerance, and describe approaches to optimize cardiovascular risk reduction among individuals reporting statin-associated muscle symptoms. (J Am Coll Cardiol 2017;70:1290-301) (C) 2017 by the American College of Cardiology Foundation. Published by Elsevier. All rights reserved.

Original language	English
Pages (from-to)	1290-1301
Number of pages	12
Journal	Journal of the American College of Cardiology
Volume	70
Issue number	10
DOIs	https://doi.org/10.1016/j.jacc.2017.07.752
Publication status	Published - 5 Sept 2017

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.jacc.2017.07.752

https://pubmed.ncbi.nlm.nih.gov/28859793/

Cite this

Rosenson, R. S., Baker, S., Banach, M., Borow, K. M., Braun, L. T., Bruckert, E., Brunham, L. R., Catapano, A. L., Elam, M. B., Mancini, G. B. J., Moriarty, P. M., Morris, P. B., Muntner, P., Ray, K. K., Stroes, E. S., Taylor, B. A., Taylor, V. H., Watts, G. F., & Thompson, P. D. (2017). Optimizing cholesterol treatment in patients with muscle complaints. Journal of the American College of Cardiology, 70(10), 1290-1301. https://doi.org/10.1016/j.jacc.2017.07.752

@article{bfdcc4d3fecf42ef9da2666c243932f3,

title = "Optimizing cholesterol treatment in patients with muscle complaints",

abstract = "Statins are highly effective for preventing cardiovascular events by reducing low-density lipoprotein cholesterol (LDL-C). However, many patients taking statins report muscle-related symptoms that prevent the use of guideline recommended doses. Patients with reported intolerance to statins have a high risk of cardiovascular events. Clinical strategies that optimize cardiovascular risk reduction through LDL-C lowering need to be applied in patients experiencing intolerable side effects that they attribute to statins. In this paper, the authors review definitions of statin intolerance, propose algorithms to better define statin intolerance, and describe approaches to optimize cardiovascular risk reduction among individuals reporting statin-associated muscle symptoms. (J Am Coll Cardiol 2017;70:1290-301) (C) 2017 by the American College of Cardiology Foundation. Published by Elsevier. All rights reserved.",

keywords = "cardiovascular disease, low-density lipoprotein, myalgia, myopathy, statin intolerance, STATIN-INTOLERANT PATIENTS, DENSITY-LIPOPROTEIN CHOLESTEROL, CARDIOVASCULAR-DISEASE, RANDOMIZED-TRIAL, SKELETAL-MUSCLE, MONOCLONAL-ANTIBODY, TASK-FORCE, MANAGEMENT, EZETIMIBE, EFFICACY",

author = "Rosenson, {Robert S.} and Steven Baker and Maciej Banach and Borow, {Kenneth M.} and Braun, {Lynne T.} and Eric Bruckert and Brunham, {Liam R.} and Catapano, {Alberico L.} and Elam, {Marshall B.} and Mancini, {G. B. John} and Moriarty, {Patrick M.} and Morris, {Pamela B.} and Paul Muntner and Ray, {Kausik K.} and Stroes, {Erik S.} and Taylor, {Beth A.} and Taylor, {Valerie H.} and Watts, {Gerald F.} and Thompson, {Paul D.}",

year = "2017",

month = sep,

day = "5",

doi = "10.1016/j.jacc.2017.07.752",

language = "English",

volume = "70",

pages = "1290--1301",

journal = "Journal of the American College of Cardiology",

issn = "0735-1097",

publisher = "Academic Press",

number = "10",

}

Rosenson, RS, Baker, S, Banach, M, Borow, KM, Braun, LT, Bruckert, E, Brunham, LR, Catapano, AL, Elam, MB, Mancini, GBJ, Moriarty, PM, Morris, PB, Muntner, P, Ray, KK, Stroes, ES, Taylor, BA, Taylor, VH, Watts, GF & Thompson, PD 2017, 'Optimizing cholesterol treatment in patients with muscle complaints', Journal of the American College of Cardiology, vol. 70, no. 10, pp. 1290-1301. https://doi.org/10.1016/j.jacc.2017.07.752

TY - JOUR

T1 - Optimizing cholesterol treatment in patients with muscle complaints

AU - Rosenson, Robert S.

AU - Baker, Steven

AU - Banach, Maciej

AU - Borow, Kenneth M.

AU - Braun, Lynne T.

AU - Bruckert, Eric

AU - Brunham, Liam R.

AU - Catapano, Alberico L.

AU - Elam, Marshall B.

AU - Mancini, G. B. John

AU - Moriarty, Patrick M.

AU - Morris, Pamela B.

AU - Muntner, Paul

AU - Ray, Kausik K.

AU - Stroes, Erik S.

AU - Taylor, Beth A.

AU - Taylor, Valerie H.

AU - Watts, Gerald F.

AU - Thompson, Paul D.

PY - 2017/9/5

Y1 - 2017/9/5

N2 - Statins are highly effective for preventing cardiovascular events by reducing low-density lipoprotein cholesterol (LDL-C). However, many patients taking statins report muscle-related symptoms that prevent the use of guideline recommended doses. Patients with reported intolerance to statins have a high risk of cardiovascular events. Clinical strategies that optimize cardiovascular risk reduction through LDL-C lowering need to be applied in patients experiencing intolerable side effects that they attribute to statins. In this paper, the authors review definitions of statin intolerance, propose algorithms to better define statin intolerance, and describe approaches to optimize cardiovascular risk reduction among individuals reporting statin-associated muscle symptoms. (J Am Coll Cardiol 2017;70:1290-301) (C) 2017 by the American College of Cardiology Foundation. Published by Elsevier. All rights reserved.

AB - Statins are highly effective for preventing cardiovascular events by reducing low-density lipoprotein cholesterol (LDL-C). However, many patients taking statins report muscle-related symptoms that prevent the use of guideline recommended doses. Patients with reported intolerance to statins have a high risk of cardiovascular events. Clinical strategies that optimize cardiovascular risk reduction through LDL-C lowering need to be applied in patients experiencing intolerable side effects that they attribute to statins. In this paper, the authors review definitions of statin intolerance, propose algorithms to better define statin intolerance, and describe approaches to optimize cardiovascular risk reduction among individuals reporting statin-associated muscle symptoms. (J Am Coll Cardiol 2017;70:1290-301) (C) 2017 by the American College of Cardiology Foundation. Published by Elsevier. All rights reserved.

KW - cardiovascular disease

KW - low-density lipoprotein

KW - myalgia

KW - myopathy

KW - statin intolerance

KW - STATIN-INTOLERANT PATIENTS

KW - DENSITY-LIPOPROTEIN CHOLESTEROL

KW - CARDIOVASCULAR-DISEASE

KW - RANDOMIZED-TRIAL

KW - SKELETAL-MUSCLE

KW - MONOCLONAL-ANTIBODY

KW - TASK-FORCE

KW - MANAGEMENT

KW - EZETIMIBE

KW - EFFICACY

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85028514852&origin=resultslist&sort=plf-f&src=s&st1=

U2 - 10.1016/j.jacc.2017.07.752

DO - 10.1016/j.jacc.2017.07.752

M3 - Review article

C2 - 28859793

SN - 0735-1097

VL - 70

SP - 1290

EP - 1301

JO - Journal of the American College of Cardiology

JF - Journal of the American College of Cardiology

IS - 10

ER -

Optimizing cholesterol treatment in patients with muscle complaints

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this