Optimization approaches for the design of additively manufactured scaffolds

Sara M. Giannitelli, Alberto Rainer, Dino Accoto, Stefano De Porcellinis, Elena M. De-Juan-Pardo, Eugenio Guglielmelli, Marcella Trombetta

Research output: Contribution to journalArticle

4 Citations (Scopus)


Scaffolds play a pivotal role in tissue engineering, promoting the synthesis of neo extra-cellularmatrix (ECM), and providing temporarymechanical support for the cells during tissue regeneration. Advances introduced by additive manufacturing techniques have significantly improved the ability to regulate scaffold architecture, enhancing the control over scaffold shape and porosity. Thus, considerable research efforts have been devoted to the fabrication of 3D porous scaffolds with optimized micro-architectural features. This chapter gives an overview of the methods for the design of additively manufactured scaffolds and their applicability in tissue engineering (TE). Along with a survey of the state of the art, the Authors will also present a recently developed method, called Load-Adaptive Scaffold Architecturing (LASA), which returns scaffold architectures optimized for given applied mechanical loads systems, once the specific stress distribution is evaluated through Finite Element Analysis (FEA).

Original languageEnglish
Pages (from-to)113-128
Number of pages16
JournalComputational Methods in Applied Sciences
Publication statusPublished - 1 Jan 2014
Externally publishedYes


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