Optimising the use of indwelling pleural catheter in the management of malignant pleural effusion

Rajesh Thomas

    Research output: ThesisDoctoral Thesis

    Abstract

    This PhD thesis explores key knowledge gaps about the benefits and safety of indwelling pleural catheters (lPC) in the treatment for malignant pleural effusions (MPEs).The major findings include i. lPC patients spent significantly fewer days in hospital compared to those who had talc pleurodesis (Australasian Malignant Pleural Effusion randomised trial); ii. lPC-related complications of symptomatic loculation and catheter tract metastasis were effectively treated by fibrinolytics and radiotherapy respectively; and iii. Pleural fluid biochemistry and cytokines change significantly with cancer progression. These novel results support the use of lPCs as first-line therapy and set the platform for future MPE research.
    LanguageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • The University of Western Australia
    Award date20 Feb 2017
    StateUnpublished - 2017

    Fingerprint

    Malignant Pleural Effusion
    Indwelling Catheters
    Pleurodesis
    Talc
    Biochemistry
    Radiotherapy
    Catheters
    Cytokines
    Neoplasm Metastasis
    Safety
    Therapeutics
    Research
    Neoplasms

    Cite this

    @phdthesis{c9ff925fda84455dbe808af5fa51eb6a,
    title = "Optimising the use of indwelling pleural catheter in the management of malignant pleural effusion",
    abstract = "This PhD thesis explores key knowledge gaps about the benefits and safety of indwelling pleural catheters (lPC) in the treatment for malignant pleural effusions (MPEs).The major findings include i. lPC patients spent significantly fewer days in hospital compared to those who had talc pleurodesis (Australasian Malignant Pleural Effusion randomised trial); ii. lPC-related complications of symptomatic loculation and catheter tract metastasis were effectively treated by fibrinolytics and radiotherapy respectively; and iii. Pleural fluid biochemistry and cytokines change significantly with cancer progression. These novel results support the use of lPCs as first-line therapy and set the platform for future MPE research.",
    keywords = "Indwelling Pleural Catheters, Malignant Pleural Effusion, Mesothelioma, Pleural effusion",
    author = "Rajesh Thomas",
    year = "2017",
    language = "English",
    school = "The University of Western Australia",

    }

    Thomas, R 2017, 'Optimising the use of indwelling pleural catheter in the management of malignant pleural effusion', Doctor of Philosophy, The University of Western Australia.

    Optimising the use of indwelling pleural catheter in the management of malignant pleural effusion. / Thomas, Rajesh.

    2017.

    Research output: ThesisDoctoral Thesis

    TY - THES

    T1 - Optimising the use of indwelling pleural catheter in the management of malignant pleural effusion

    AU - Thomas,Rajesh

    PY - 2017

    Y1 - 2017

    N2 - This PhD thesis explores key knowledge gaps about the benefits and safety of indwelling pleural catheters (lPC) in the treatment for malignant pleural effusions (MPEs).The major findings include i. lPC patients spent significantly fewer days in hospital compared to those who had talc pleurodesis (Australasian Malignant Pleural Effusion randomised trial); ii. lPC-related complications of symptomatic loculation and catheter tract metastasis were effectively treated by fibrinolytics and radiotherapy respectively; and iii. Pleural fluid biochemistry and cytokines change significantly with cancer progression. These novel results support the use of lPCs as first-line therapy and set the platform for future MPE research.

    AB - This PhD thesis explores key knowledge gaps about the benefits and safety of indwelling pleural catheters (lPC) in the treatment for malignant pleural effusions (MPEs).The major findings include i. lPC patients spent significantly fewer days in hospital compared to those who had talc pleurodesis (Australasian Malignant Pleural Effusion randomised trial); ii. lPC-related complications of symptomatic loculation and catheter tract metastasis were effectively treated by fibrinolytics and radiotherapy respectively; and iii. Pleural fluid biochemistry and cytokines change significantly with cancer progression. These novel results support the use of lPCs as first-line therapy and set the platform for future MPE research.

    KW - Indwelling Pleural Catheters

    KW - Malignant Pleural Effusion

    KW - Mesothelioma

    KW - Pleural effusion

    M3 - Doctoral Thesis

    ER -