Optimising the management of pleural infection and pleural malignancy

Deirdre Fitzgerald

Research output: ThesisDoctoral Thesis

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Abstract

This research aimed to optimise management of parapneumonic and malignant pleural effusion (MPE). Results indicated that systemic corticosteroids are not beneficial vs placebo in parapneumonic effusion. Assessing relationships between pleural fluid biomarkers demonstrated that pH and glucose have a strong but non-linear relationship; trace elements are present at biologically relevant levels. Intrapleural fibrinolytic/enzyme therapy was safe and effective in indwelling pleural catheter (IPC)-related pleural infection. In symptomatic effusion, the contralateral hemidiaphragm compensates for the ipsilateral hemidiaphragm impairment. A study protocol for a randomised trial comparing IPC to video-assisted thoracoscopic surgery for MPE was developed and the study is actively recruiting.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Lee, Gary, Supervisor
  • Waterer, Grant, Supervisor
Thesis sponsors
Award date9 Jun 2023
DOIs
Publication statusUnpublished - 2022

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