Research output per year
Research output per year
Abstract
This research aimed to optimise management of parapneumonic and malignant pleural effusion (MPE). Results indicated that systemic corticosteroids are not beneficial vs placebo in parapneumonic effusion. Assessing relationships between pleural fluid biomarkers demonstrated that pH and glucose have a strong but non-linear relationship; trace elements are present at biologically relevant levels. Intrapleural fibrinolytic/enzyme therapy was safe and effective in indwelling pleural catheter (IPC)-related pleural infection. In symptomatic effusion, the contralateral hemidiaphragm compensates for the ipsilateral hemidiaphragm impairment. A study protocol for a randomised trial comparing IPC to video-assisted thoracoscopic surgery for MPE was developed and the study is actively recruiting.
| Original language | English |
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| Qualification | Doctor of Philosophy |
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| Award date | 9 Jun 2023 |
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| Publication status | Unpublished - 2022 |
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Dive into the research topics of 'Optimising the management of pleural infection and pleural malignancy'. Together they form a unique fingerprint.Research output
- 7 Article
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Australasian Malignant PLeural Effusion (AMPLE)-3 trial: study protocol for a multi-centre randomised study comparing indwelling pleural catheter (±talc pleurodesis) versus video-assisted thoracoscopic surgery for management of malignant pleural effusion
Fitzgerald, D. B., Sidhu, C., Budgeon, C., Tan, A. L., Read, C. A., Kwan, B. C. H., Smith, N. A., Fysh, E. T., Muruganandan, S., Saghaie, T., Shrestha, R., Badiei, A., Nguyen, P., Burke, A., Goddard, J., Windsor, M., McDonald, J., Wright, G., Czarnecka, K. & Sivakumar, P. & 5 others, , Dec 2022, In: Trials. 23, 1, 530.Research output: Contribution to journal › Article › peer-review
Open Access13 Citations (Scopus) -
Ipsilateral and contralateral hemidiaphragm dynamics in symptomatic pleural effusion: The 2nd PLeural Effusion And Symptom Evaluation (PLEASE-2) Study
Fitzgerald, D. B., Muruganandan, S., Peddle-McIntyre, C. J., Lee, Y. C. G. & Singh, B., Oct 2022, In: Respirology. 27, 10, p. 882-889 8 p.Research output: Contribution to journal › Article › peer-review
10 Citations (Scopus) -
The Steroid Therapy and Outcome of Parapneumonic Pleural Effusions (STOPPE): A Pilot Randomized Trial
Fitzgerald, D. B., Waterer, G. W., Budgeon, C., Shrestha, R., Fysh, E. T., Muruganandan, S., Stanley, C., Saghaie, T., Badiei, A., Sidhu, C., Harryanto, H., Duong, V., Azzopardi, M., Manners, D., Lan, N. S. H., Popowicz, N. D., Peddle-McIntyre, C. J., Rahman, N. M., Read, C. A. & Tan, A. L. & 3 others, , 1 May 2022, In: American Journal of Respiratory and Critical Care Medicine. 205, 9, p. 1093-1101 9 p.Research output: Contribution to journal › Article › peer-review
14 Citations (Web of Science)