Optimising Novel Therapies for Pleural Infection

Research output: ThesisDoctoral Thesis

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Abstract

This PhD thesis explored aspects of pleural fluid drainage and antibiotic optimisation in pleural infection. The benefit of intrapleural tissue plasminogen activator and deoxyribonuclease reported through this research has contributed to pleural infection management. Bacteriology data of pleural infection in Australia will guide antibiotic selection. Significant advances towards understanding the pathobiology of pleural infection, specifically bacterial interactions within pleural fluid, offer opportunities to identify novel therapeutic targets. Finally, development of an analytical method for quantification of piperacillin and tazobactam levels within pleural fluid offers insights into pleural pharmacokinetics. The results presented contribute to optimising novel therapies for pleural infection.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Lee, Gary, Supervisor
  • Waterer, Grant, Supervisor
Thesis sponsors
Award date10 Jun 2020
DOIs
Publication statusUnpublished - 2020

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