Optimised robust treatment plans for prostate cancer focal brachytherapy

J.M. Betts, C. Mears, H.M. Reynolds, G. Tack, K. Leo, Martin Ebert, A. Haworth

    Research output: Chapter in Book/Conference paperConference paperpeer-review

    11 Citations (Scopus)


    © The Authors. Published by Elsevier B.V. Focal brachytherapy is a clinical procedure that can be used to treat low-risk prostate cancer with reduced side-effects compared to conventional brachytherapy. Current practice is to manually plan the placement of radioactive seeds inside the prostate to achieve a desired treatment dose. Problems with the current practice are that the manual planning is time-consuming and high doses to the urethra and rectum cause undesirable side-effects. To address this problem, we have designed an optimisation algorithm that constructs treatment plans which achieve the desired dose while minimizing dose to organs at risk. We also show that these seed plans are robust to post-operative movement of the seeds within the prostate.
    Original languageEnglish
    Title of host publicationProcedia Computer Science
    Place of PublicationNetherlands
    ISBN (Print)18770509
    Publication statusPublished - 2015
    EventICCS 2015 International Conference On Computational Science - Reykjavík, Iceland
    Duration: 1 Jun 20153 Jun 2015


    ConferenceICCS 2015 International Conference On Computational Science


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