Optical palpation for the visualization of tumor in human breast tissue

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Accurate and effective removal of tumor in one operation is an important goal of breast-conserving surgery. However, it is not always achieved. Surgeons often utilize manual palpation to assess the surgical margin and/or the breast cavity. Manual palpation, however, is subjective and has relatively low resolution. Here, we investigate a tactile imaging technique, optical palpation, for the visualization of tumor. Optical palpation generates maps of the stress at the surface of tissue under static preload compression. Stress is evaluated by measuring the deformation of a contacting thin compliant layer with known mechanical properties using optical coherence tomography. In this study, optical palpation is performed on 34 freshly excised human breast specimens. Wide field-of-view (up to similar to 46 x 46 mm) stress images, optical palpograms, are presented from four representative specimens, demonstrating the capability of optical palpation to visualize tumor. Median stress reported for adipose tissue, 4 kPa, and benign dense tissue, 8 kPa, is significantly lower than for invasive tumor, 60 kPa. In addition, we demonstrate that optical palpation provides contrast consistent with a related optical technique, quantitative micro-elastography. This study demonstrates that optical palpation holds promise for visualization of tumor in breast-conserving surgery.

Original languageEnglish
Article number201800180
Number of pages11
JournalJournal of Biophotonics
Volume12
Issue number1
DOIs
Publication statusPublished - Jan 2019

Cite this

@article{eb9c794332734bc59ae9ef04f852faae,
title = "Optical palpation for the visualization of tumor in human breast tissue",
abstract = "Accurate and effective removal of tumor in one operation is an important goal of breast-conserving surgery. However, it is not always achieved. Surgeons often utilize manual palpation to assess the surgical margin and/or the breast cavity. Manual palpation, however, is subjective and has relatively low resolution. Here, we investigate a tactile imaging technique, optical palpation, for the visualization of tumor. Optical palpation generates maps of the stress at the surface of tissue under static preload compression. Stress is evaluated by measuring the deformation of a contacting thin compliant layer with known mechanical properties using optical coherence tomography. In this study, optical palpation is performed on 34 freshly excised human breast specimens. Wide field-of-view (up to similar to 46 x 46 mm) stress images, optical palpograms, are presented from four representative specimens, demonstrating the capability of optical palpation to visualize tumor. Median stress reported for adipose tissue, 4 kPa, and benign dense tissue, 8 kPa, is significantly lower than for invasive tumor, 60 kPa. In addition, we demonstrate that optical palpation provides contrast consistent with a related optical technique, quantitative micro-elastography. This study demonstrates that optical palpation holds promise for visualization of tumor in breast-conserving surgery.",
keywords = "breast-conserving surgery, optical coherence tomography, optical palpation, tactile imaging, tumor margin assessment, QUANTITATIVE MICRO-ELASTOGRAPHY, INTRAOPERATIVE MARGIN ASSESSMENT, TACTILE SPATIAL-RESOLUTION, COHERENCE TOMOGRAPHY, CONSERVING SURGERY, IMPRINT CYTOLOGY, SURGICAL MARGINS, RE-EXCISION, PREDICTORS, CANCER",
author = "Allen, {Wes M.} and Philip Wijesinghe and Dessauvagie, {Benjamin F.} and Bruce Latham and Saunders, {Christobel M.} and Kennedy, {Brendan F.}",
year = "2019",
month = "1",
doi = "10.1002/jbio.201800180",
language = "English",
volume = "12",
journal = "Journal of Biophotonics",
issn = "1864-0648",
publisher = "Wiley-VCH Verlag GmbH & Co. KGaA",
number = "1",

}

TY - JOUR

T1 - Optical palpation for the visualization of tumor in human breast tissue

AU - Allen, Wes M.

AU - Wijesinghe, Philip

AU - Dessauvagie, Benjamin F.

AU - Latham, Bruce

AU - Saunders, Christobel M.

AU - Kennedy, Brendan F.

PY - 2019/1

Y1 - 2019/1

N2 - Accurate and effective removal of tumor in one operation is an important goal of breast-conserving surgery. However, it is not always achieved. Surgeons often utilize manual palpation to assess the surgical margin and/or the breast cavity. Manual palpation, however, is subjective and has relatively low resolution. Here, we investigate a tactile imaging technique, optical palpation, for the visualization of tumor. Optical palpation generates maps of the stress at the surface of tissue under static preload compression. Stress is evaluated by measuring the deformation of a contacting thin compliant layer with known mechanical properties using optical coherence tomography. In this study, optical palpation is performed on 34 freshly excised human breast specimens. Wide field-of-view (up to similar to 46 x 46 mm) stress images, optical palpograms, are presented from four representative specimens, demonstrating the capability of optical palpation to visualize tumor. Median stress reported for adipose tissue, 4 kPa, and benign dense tissue, 8 kPa, is significantly lower than for invasive tumor, 60 kPa. In addition, we demonstrate that optical palpation provides contrast consistent with a related optical technique, quantitative micro-elastography. This study demonstrates that optical palpation holds promise for visualization of tumor in breast-conserving surgery.

AB - Accurate and effective removal of tumor in one operation is an important goal of breast-conserving surgery. However, it is not always achieved. Surgeons often utilize manual palpation to assess the surgical margin and/or the breast cavity. Manual palpation, however, is subjective and has relatively low resolution. Here, we investigate a tactile imaging technique, optical palpation, for the visualization of tumor. Optical palpation generates maps of the stress at the surface of tissue under static preload compression. Stress is evaluated by measuring the deformation of a contacting thin compliant layer with known mechanical properties using optical coherence tomography. In this study, optical palpation is performed on 34 freshly excised human breast specimens. Wide field-of-view (up to similar to 46 x 46 mm) stress images, optical palpograms, are presented from four representative specimens, demonstrating the capability of optical palpation to visualize tumor. Median stress reported for adipose tissue, 4 kPa, and benign dense tissue, 8 kPa, is significantly lower than for invasive tumor, 60 kPa. In addition, we demonstrate that optical palpation provides contrast consistent with a related optical technique, quantitative micro-elastography. This study demonstrates that optical palpation holds promise for visualization of tumor in breast-conserving surgery.

KW - breast-conserving surgery

KW - optical coherence tomography

KW - optical palpation

KW - tactile imaging

KW - tumor margin assessment

KW - QUANTITATIVE MICRO-ELASTOGRAPHY

KW - INTRAOPERATIVE MARGIN ASSESSMENT

KW - TACTILE SPATIAL-RESOLUTION

KW - COHERENCE TOMOGRAPHY

KW - CONSERVING SURGERY

KW - IMPRINT CYTOLOGY

KW - SURGICAL MARGINS

KW - RE-EXCISION

KW - PREDICTORS

KW - CANCER

U2 - 10.1002/jbio.201800180

DO - 10.1002/jbio.201800180

M3 - Article

VL - 12

JO - Journal of Biophotonics

JF - Journal of Biophotonics

SN - 1864-0648

IS - 1

M1 - 201800180

ER -