Optical coherence tomography angiography helps distinguish multiple sclerosis from AQP4-IgG-seropositive neuromyelitis optica spectrum disorder

Chunxin Liu, Hui Xiao, Xiayin Zhang, Yipeng Zhao, Rui Li, Xiaonan Zhong, Yuge Wang, Yaqing Shu, Yanyu Chang, Jingqi Wang, Caixia Li, Haotian Lin, Wei Qiu

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10 Citations (Scopus)

Abstract

Introduction: The aim was to characterize the optical coherence tomography (OCT) angiography measures in patients with multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) and to evaluate their disease discrimination capacity. Methods: Patients with MS (n = 83) and AQP4-IgG-seropositive NMOSD (n = 91) with or without a history of optic neuritis, together with healthy controls (n = 34), were imaged. The main outcome measures were peripapillary retinal nerve fiber layer (pRNFL) thickness, macular ganglion cell-inner plexiform layer (GC-IPL) thickness, macular vessel density (VD), and perfusion density (PD) in the superficial capillary plexus. Diagnostic accuracy was assessed using the area under the receiver operating characteristics curve. Results: Compared with patients with MS, those with NMOSD had a significantly smaller average thickness of the pRNFL and GC-IPL (80.0 [59.0; 95.8] μm versus 92.0 [80.2; 101] μm, p
Original languageEnglish
Article numbere02125
JournalBrain and Behavior
Volume11
Issue number5
DOIs
Publication statusPublished - May 2021
Externally publishedYes

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