@article{f8483a6d6d7b4e82b9cc8af75c6aa8dd,
title = "Optical coherence tomography angiography helps distinguish multiple sclerosis from AQP4-IgG-seropositive neuromyelitis optica spectrum disorder",
abstract = "Introduction: The aim was to characterize the optical coherence tomography (OCT) angiography measures in patients with multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) and to evaluate their disease discrimination capacity. Methods: Patients with MS (n = 83) and AQP4-IgG-seropositive NMOSD (n = 91) with or without a history of optic neuritis, together with healthy controls (n = 34), were imaged. The main outcome measures were peripapillary retinal nerve fiber layer (pRNFL) thickness, macular ganglion cell-inner plexiform layer (GC-IPL) thickness, macular vessel density (VD), and perfusion density (PD) in the superficial capillary plexus. Diagnostic accuracy was assessed using the area under the receiver operating characteristics curve. Results: Compared with patients with MS, those with NMOSD had a significantly smaller average thickness of the pRNFL and GC-IPL (80.0 [59.0; 95.8] μm versus 92.0 [80.2; 101] μm, p ",
keywords = "multiple sclerosis, neuromyelitis optica spectrum disorder, optical coherence tomography angiography",
author = "Chunxin Liu and Hui Xiao and Xiayin Zhang and Yipeng Zhao and Rui Li and Xiaonan Zhong and Yuge Wang and Yaqing Shu and Yanyu Chang and Jingqi Wang and Caixia Li and Haotian Lin and Wei Qiu",
note = "Funding Information: The authors thank the MED Department, Carl Zeiss (Shanghai) Co. Ltd., ZEISS Group, for the supplied devices and technical support, especially Sheng Yang, Yaowu Huang, and Sijian Zhang for their technical support with the high‐definition OCT and AngioPlex device. This work was supported by grants from the National Natural Science Foundation of China (81771300, 81971140), the Natural Science Foundation of Guangdong Province (2017A030313853), and the Guangzhou Science and Technology Plan Project (201904010444). Funding Information: The authors thank the MED Department, Carl Zeiss (Shanghai) Co. Ltd., ZEISS Group, for the supplied devices and technical support, especially Sheng Yang, Yaowu Huang, and Sijian Zhang for their technical support with the high-definition OCT and AngioPlex device. This work was supported by grants from the National Natural Science Foundation of China (81771300, 81971140), the Natural Science Foundation of Guangdong Province (2017A030313853), and the Guangzhou Science and Technology Plan Project (201904010444). Publisher Copyright: {\textcopyright} 2021 The Authors. Brain and Behavior published by Wiley Periodicals LLC",
year = "2021",
month = may,
doi = "10.1002/brb3.2125",
language = "English",
volume = "11",
journal = "Brain and Behavior",
issn = "2162-3279",
publisher = "John Wiley & Sons",
number = "5",
}