Optical coherence elastography for cellular-scale stiffness imaging of mouse aorta

Philip Wijesinghe, Niloufer J. Johansen, Andrea Curatolo, David D. Sampson, Ruth Ganss, Brendan F. Kennedy

Research output: Chapter in Book/Conference paperConference paper

Abstract

We have developed a high-resolution optical coherence elastography system capable of estimating Young's modulus in tissue volumes with an isotropic resolution of 15 μm over a 1 mm lateral field of view and a 100 μm axial depth of field. We demonstrate our technique on healthy and hypertensive, freshly excised and intact mouse aortas. Our technique has the capacity to delineate the individual mechanics of elastic lamellae and vascular smooth muscle. Further, we observe global and regional vascular stiffening in hypertensive aortas, and note the presence of local micro-mechanical signatures, characteristic of fibrous and lipid-rich regions.

Original languageEnglish
Title of host publicationInternational Conference on Biophotonics V
EditorsDavid D. Sampson, Dennis L. Matthews, Jürgen Popp, Halina Rubinsztein-Dunlop, Brian C. Wilson
Place of PublicationUSA
PublisherSPIE
Volume10340
ISBN (Electronic)9781510611269
ISBN (Print)9781510611252
DOIs
Publication statusPublished - 2017
Event5th International Conference on Biophotonics - Perth, Australia
Duration: 30 Apr 20171 May 2017

Publication series

NameProgress in Biomedical Optics and Imaging
Number58
Volume18

Conference

Conference5th International Conference on Biophotonics
Abbreviated titleICOB 2017
CountryAustralia
CityPerth
Period30/04/171/05/17

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