@inproceedings{e43b1e60dfec42ad9aaad163a6a593b7,
title = "Optical coherence elastography for cellular-scale stiffness imaging of mouse aorta",
abstract = "We have developed a high-resolution optical coherence elastography system capable of estimating Young's modulus in tissue volumes with an isotropic resolution of 15 μm over a 1 mm lateral field of view and a 100 μm axial depth of field. We demonstrate our technique on healthy and hypertensive, freshly excised and intact mouse aortas. Our technique has the capacity to delineate the individual mechanics of elastic lamellae and vascular smooth muscle. Further, we observe global and regional vascular stiffening in hypertensive aortas, and note the presence of local micro-mechanical signatures, characteristic of fibrous and lipid-rich regions.",
author = "Philip Wijesinghe and Johansen, {Niloufer J.} and Andrea Curatolo and Sampson, {David D.} and Ruth Ganss and Kennedy, {Brendan F.}",
year = "2017",
doi = "10.1117/12.2269903",
language = "English",
isbn = "9781510611252",
volume = "10340",
series = "Progress in Biomedical Optics and Imaging",
publisher = "SPIE",
number = "58",
editor = "Sampson, {David D. } and Matthews, {Dennis L. } and Popp, {J{\"u}rgen } and Rubinsztein-Dunlop, {Halina } and Wilson, {Brian C. }",
booktitle = "International Conference on Biophotonics V",
address = "United States",
note = "5th International Conference on Biophotonics, ICOB 2017 ; Conference date: 30-04-2017 Through 01-05-2017",
}