Opposite gene by environment interactions in Karelia for CD14 and CC16 single nucleotide polymorphisms and allergy

G. Zhang, Siew-Kim Khoo, T. Laatikainen, P. Pekkarinen, E. Vartiainen, L. Von Hertzen, Catherine Hayden, Jack Goldblatt, M. Makela, T. Haahtela, Peter Le Souef

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    34 Citations (Scopus)

    Abstract

    Background:  Finnish Karelians have a higher prevalence of allergic disease than Russian Karelians. As both populations are generally from the same ethnic group, the Karelian population offers a unique opportunity to analyse genetic and allergic disease interactions between ‘Western’ and ‘Eastern’ environments.Objectives:  We investigated associations between allergic diseases and CD14 and CC16 polymorphisms in Finnish vs Russian Karelian women.Methods:  Adult female Karelians (330 Finnish and 274 Russian) were recruited, examined for a range of symptoms and conditions including rhinitis, itchy rash, asthma and atopy and genotyped for CD14 C-159T and CC16 A38G.Results:  For both CD14 C-159T and CC16 A38G, the risk allele for atopic phenotypes in Finnish Karelia was the protective allele in Russian Karelia. For CD14 C-159T, an interactive effect on ever itchy rash (Pinteraction = 0.004), itchy rash
    Original languageEnglish
    Pages (from-to)doi:10.1111/j.1398-9995.2009.02006
    JournalAllergy
    Volume64
    Issue number9
    DOIs
    Publication statusPublished - 2009

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