One-electron reduction potential of the neutral guanyl radical in the gc base pair of duplex DNA

Sujata S. Shinde; Andrej Maroz; Michael P. Hay; Robert F. Anderson

doi:10.1021/ja8087339

One-electron reduction potential of the neutral guanyl radical in the gc base pair of duplex DNA

Sujata S. Shinde, Andrej Maroz, Michael P. Hay, Robert F. Anderson

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Abstract

The one-electron oxidation of guanine in the GC base pair of DNA has been investigated using pulse radiolysis combined with DFT calculations. Reaction of benzotriazinyl radicals with DNA results in the formation of the neutral guanyl radical and redox equilibria. The one-electron reduction potential, E ₇, of the neutral guanyl radical in the GC base pair is determined for the first time as 1.22 ±0.02 V, from both absorption and kinetic data.

Original language	English
Pages (from-to)	5203-5207
Number of pages	5
Journal	Journal of the American Chemical Society
Volume	131
Issue number	14
DOIs	https://doi.org/10.1021/ja8087339
Publication status	Published - 15 Apr 2009
Externally published	Yes

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abstract = "The one-electron oxidation of guanine in the GC base pair of DNA has been investigated using pulse radiolysis combined with DFT calculations. Reaction of benzotriazinyl radicals with DNA results in the formation of the neutral guanyl radical and redox equilibria. The one-electron reduction potential, E 7, of the neutral guanyl radical in the GC base pair is determined for the first time as 1.22 ±0.02 V, from both absorption and kinetic data.",

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AU - Shinde, Sujata S.

AU - Maroz, Andrej

AU - Hay, Michael P.

AU - Anderson, Robert F.

PY - 2009/4/15

Y1 - 2009/4/15

N2 - The one-electron oxidation of guanine in the GC base pair of DNA has been investigated using pulse radiolysis combined with DFT calculations. Reaction of benzotriazinyl radicals with DNA results in the formation of the neutral guanyl radical and redox equilibria. The one-electron reduction potential, E 7, of the neutral guanyl radical in the GC base pair is determined for the first time as 1.22 ±0.02 V, from both absorption and kinetic data.

AB - The one-electron oxidation of guanine in the GC base pair of DNA has been investigated using pulse radiolysis combined with DFT calculations. Reaction of benzotriazinyl radicals with DNA results in the formation of the neutral guanyl radical and redox equilibria. The one-electron reduction potential, E 7, of the neutral guanyl radical in the GC base pair is determined for the first time as 1.22 ±0.02 V, from both absorption and kinetic data.

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One-electron reduction potential of the neutral guanyl radical in the gc base pair of duplex DNA

Abstract

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