Omega-3 Fatty acids-3 fatty acid ethyl esters diminish postprandial lipemia in familial hypercholesterolemia

Dick Chan, Jing Pang, Hugh Barrett, D.R. Sullivan, John Burnett, Frank Van Bockxmeer, Gerald Watts

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Abstract

© 2016 by the Endocrine Society. CONTEXT: Impaired postprandial chylomicron metabolism induces hypertriglyceridemia and may increase the risk of atherosclerotic cardiovascular disease. Omega-3 fatty acid ethyl ester (ω-3 FAEE) supplementation decreases plasma triglycerides. However, its effect on postprandial chylomicron metabolism in familial hypercholesterolemia (FH) has not yet been investigated. OBJECTIVE: We aimed to examine the effect of ω-3 FAEE supplementation on postprandial responses in plasma triglycerides, very-low-density lipoprotein (VLDL) apolipoprotein B (apoB)-100, and apoB-48 in FH patients receiving standard cholesterol-lowering treatment. DESIGN, SETTING, AND PATIENTS: We carried out an 8-week open-label, randomized, crossover intervention trial to test the effect of oral supplementation with 4 g/d ω-3 FAEE (46% eicosapentaenoic acid and 38% docosahexaenoic acid) on postprandial triglyceride, VLDL-apoB-100, and apoB-48 responses in FH patients after ingestion of an oral fat load. OUTCOMES MEASURES: Plasma total and incremental triglyceride, VLDL-apoB-100, and apoB-48 0- to 10-hour area under the curve (AUC). RESULTS: ω-3 FAEE supplementation significantly (P <.05 in all) reduced concentrations of fasting plasma triglyceride (-20%), apoB (-8%), VLDL-apoB-100 (-26%), and apoB-48 (-36%); as well as systolic blood pressure (-6%) and diastolic blood pressure (-6%). Postprandial triglyceride and VLDL-apoB-100 total AUCs (-19% and -26%, respectively; P <.01) and incremental AUCs (-18% and -35%, respectively; P <.05), as well as postprandial apoB-48 total AUC (-30%; P <.02) were significantly reduced by ω-3 FAEE supplementation. CONCLUSION: Supplementation with ω-3 FAEEs improves postprandial lipemia in FH patients receiving standard care; this may have implications for further reducing atherosclerotic cardiovascular disease in this high-risk patient group.
Original languageEnglish
Pages (from-to)3732-3739
Number of pages8
JournalJournal of Clinical Endocrinology and Metabolism
Volume101
Issue number10
Early online date4 Aug 2016
DOIs
Publication statusPublished - Oct 2016

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Apolipoprotein B-48
Apolipoprotein B-100
Hyperlipoproteinemia Type II
Omega-3 Fatty Acids
Hyperlipidemias
Esters
Fatty Acids
Area Under Curve
Blood Pressure
Plasmas
Chylomicrons
Blood pressure
Metabolism
Triglycerides
Cardiovascular Diseases
Eicosapentaenoic Acid
VLDL Lipoproteins
Docosahexaenoic Acids
Hypertriglyceridemia
Apolipoproteins B

Cite this

@article{4df0cb5767e94ebe8f244807ed2a301c,
title = "Omega-3 Fatty acids-3 fatty acid ethyl esters diminish postprandial lipemia in familial hypercholesterolemia",
abstract = "{\circledC} 2016 by the Endocrine Society. CONTEXT: Impaired postprandial chylomicron metabolism induces hypertriglyceridemia and may increase the risk of atherosclerotic cardiovascular disease. Omega-3 fatty acid ethyl ester (ω-3 FAEE) supplementation decreases plasma triglycerides. However, its effect on postprandial chylomicron metabolism in familial hypercholesterolemia (FH) has not yet been investigated. OBJECTIVE: We aimed to examine the effect of ω-3 FAEE supplementation on postprandial responses in plasma triglycerides, very-low-density lipoprotein (VLDL) apolipoprotein B (apoB)-100, and apoB-48 in FH patients receiving standard cholesterol-lowering treatment. DESIGN, SETTING, AND PATIENTS: We carried out an 8-week open-label, randomized, crossover intervention trial to test the effect of oral supplementation with 4 g/d ω-3 FAEE (46{\%} eicosapentaenoic acid and 38{\%} docosahexaenoic acid) on postprandial triglyceride, VLDL-apoB-100, and apoB-48 responses in FH patients after ingestion of an oral fat load. OUTCOMES MEASURES: Plasma total and incremental triglyceride, VLDL-apoB-100, and apoB-48 0- to 10-hour area under the curve (AUC). RESULTS: ω-3 FAEE supplementation significantly (P <.05 in all) reduced concentrations of fasting plasma triglyceride (-20{\%}), apoB (-8{\%}), VLDL-apoB-100 (-26{\%}), and apoB-48 (-36{\%}); as well as systolic blood pressure (-6{\%}) and diastolic blood pressure (-6{\%}). Postprandial triglyceride and VLDL-apoB-100 total AUCs (-19{\%} and -26{\%}, respectively; P <.01) and incremental AUCs (-18{\%} and -35{\%}, respectively; P <.05), as well as postprandial apoB-48 total AUC (-30{\%}; P <.02) were significantly reduced by ω-3 FAEE supplementation. CONCLUSION: Supplementation with ω-3 FAEEs improves postprandial lipemia in FH patients receiving standard care; this may have implications for further reducing atherosclerotic cardiovascular disease in this high-risk patient group.",
author = "Dick Chan and Jing Pang and Hugh Barrett and D.R. Sullivan and John Burnett and {Van Bockxmeer}, Frank and Gerald Watts",
year = "2016",
month = "10",
doi = "10.1210/jc.2016-2217",
language = "English",
volume = "101",
pages = "3732--3739",
journal = "Journal of Endocrinology & Metabolism",
issn = "0021-972X",
publisher = "ENDOCRINE SOC",
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}

TY - JOUR

T1 - Omega-3 Fatty acids-3 fatty acid ethyl esters diminish postprandial lipemia in familial hypercholesterolemia

AU - Chan, Dick

AU - Pang, Jing

AU - Barrett, Hugh

AU - Sullivan, D.R.

AU - Burnett, John

AU - Van Bockxmeer, Frank

AU - Watts, Gerald

PY - 2016/10

Y1 - 2016/10

N2 - © 2016 by the Endocrine Society. CONTEXT: Impaired postprandial chylomicron metabolism induces hypertriglyceridemia and may increase the risk of atherosclerotic cardiovascular disease. Omega-3 fatty acid ethyl ester (ω-3 FAEE) supplementation decreases plasma triglycerides. However, its effect on postprandial chylomicron metabolism in familial hypercholesterolemia (FH) has not yet been investigated. OBJECTIVE: We aimed to examine the effect of ω-3 FAEE supplementation on postprandial responses in plasma triglycerides, very-low-density lipoprotein (VLDL) apolipoprotein B (apoB)-100, and apoB-48 in FH patients receiving standard cholesterol-lowering treatment. DESIGN, SETTING, AND PATIENTS: We carried out an 8-week open-label, randomized, crossover intervention trial to test the effect of oral supplementation with 4 g/d ω-3 FAEE (46% eicosapentaenoic acid and 38% docosahexaenoic acid) on postprandial triglyceride, VLDL-apoB-100, and apoB-48 responses in FH patients after ingestion of an oral fat load. OUTCOMES MEASURES: Plasma total and incremental triglyceride, VLDL-apoB-100, and apoB-48 0- to 10-hour area under the curve (AUC). RESULTS: ω-3 FAEE supplementation significantly (P <.05 in all) reduced concentrations of fasting plasma triglyceride (-20%), apoB (-8%), VLDL-apoB-100 (-26%), and apoB-48 (-36%); as well as systolic blood pressure (-6%) and diastolic blood pressure (-6%). Postprandial triglyceride and VLDL-apoB-100 total AUCs (-19% and -26%, respectively; P <.01) and incremental AUCs (-18% and -35%, respectively; P <.05), as well as postprandial apoB-48 total AUC (-30%; P <.02) were significantly reduced by ω-3 FAEE supplementation. CONCLUSION: Supplementation with ω-3 FAEEs improves postprandial lipemia in FH patients receiving standard care; this may have implications for further reducing atherosclerotic cardiovascular disease in this high-risk patient group.

AB - © 2016 by the Endocrine Society. CONTEXT: Impaired postprandial chylomicron metabolism induces hypertriglyceridemia and may increase the risk of atherosclerotic cardiovascular disease. Omega-3 fatty acid ethyl ester (ω-3 FAEE) supplementation decreases plasma triglycerides. However, its effect on postprandial chylomicron metabolism in familial hypercholesterolemia (FH) has not yet been investigated. OBJECTIVE: We aimed to examine the effect of ω-3 FAEE supplementation on postprandial responses in plasma triglycerides, very-low-density lipoprotein (VLDL) apolipoprotein B (apoB)-100, and apoB-48 in FH patients receiving standard cholesterol-lowering treatment. DESIGN, SETTING, AND PATIENTS: We carried out an 8-week open-label, randomized, crossover intervention trial to test the effect of oral supplementation with 4 g/d ω-3 FAEE (46% eicosapentaenoic acid and 38% docosahexaenoic acid) on postprandial triglyceride, VLDL-apoB-100, and apoB-48 responses in FH patients after ingestion of an oral fat load. OUTCOMES MEASURES: Plasma total and incremental triglyceride, VLDL-apoB-100, and apoB-48 0- to 10-hour area under the curve (AUC). RESULTS: ω-3 FAEE supplementation significantly (P <.05 in all) reduced concentrations of fasting plasma triglyceride (-20%), apoB (-8%), VLDL-apoB-100 (-26%), and apoB-48 (-36%); as well as systolic blood pressure (-6%) and diastolic blood pressure (-6%). Postprandial triglyceride and VLDL-apoB-100 total AUCs (-19% and -26%, respectively; P <.01) and incremental AUCs (-18% and -35%, respectively; P <.05), as well as postprandial apoB-48 total AUC (-30%; P <.02) were significantly reduced by ω-3 FAEE supplementation. CONCLUSION: Supplementation with ω-3 FAEEs improves postprandial lipemia in FH patients receiving standard care; this may have implications for further reducing atherosclerotic cardiovascular disease in this high-risk patient group.

U2 - 10.1210/jc.2016-2217

DO - 10.1210/jc.2016-2217

M3 - Article

VL - 101

SP - 3732

EP - 3739

JO - Journal of Endocrinology & Metabolism

JF - Journal of Endocrinology & Metabolism

SN - 0021-972X

IS - 10

ER -