Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 45-51 |
| Journal | Clinical Science |
| Volume | 125 |
| Issue number | 1 |
| Early online date | 28 Jan 2013 |
| DOIs | |
| Publication status | Published - Jul 2013 |
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Omega-3 fatty acid ethyl ester supplementation decreases very-low-density lipoprotein triacylglycerol secretion in obese men. / Wong, A.T.Y.; Chan, Dick; Ooi, Esther; Ng, Theodore Wai; Watts, Gerald; Barrett, Hugh.
In: Clinical Science, Vol. 125, No. 1, 07.2013, p. 45-51.Research output: Contribution to journal › Article
TY - JOUR
T1 - Omega-3 fatty acid ethyl ester supplementation decreases very-low-density lipoprotein triacylglycerol secretion in obese men
AU - Wong, A.T.Y.
AU - Chan, Dick
AU - Ooi, Esther
AU - Ng, Theodore Wai
AU - Watts, Gerald
AU - Barrett, Hugh
PY - 2013/7
Y1 - 2013/7
N2 - Dysregulated VLDL-TAG (very-low-density lipoprotein triacylglycerol) metabolism in obesity may account for hypertriacylglycerolaemia and increased cardiovascular disease. ω-3 FAEEs (omega-3 fatty acid ethyl esters) decrease plasma TAG and VLDL concentrations, but the mechanisms are not fully understood. In the present study, we carried out a 6-week randomized, placebo-controlled study to examine the effectof high-dose ω-3 FAEE supplementation (3.2 g/day) on the metabolism of VLDL-TAG in obese men using intravenous administration of d5-glycerol. We also explored the relationship of VLDL-TAG kinetics with the metabolism of VLDL-apo (apolipoprotein) B-100 and HDL (high-density lipoprotein)-apoA-I. VLDL-TAG isotopic enrichment was measured using gas chromatography-mass spectrometry. Kinetic parameters were derived using a multicompartmental model. Compared with placebo, ω-3 FAEE supplementation significantly lowered plasma concentrations of total (-14%, P0.05). Our results suggest that the TAG-lowering effect of ω-3 FAEEs is associated with the decreased VLDL-TAG secretion rate and hence lower plasma VLDL-TAG concentration in obesity. The changes in VLDL-TAG and apoB-100 kinetics are closely coupled. © The Authors Journal compilation 2013 Biochemical Society.
AB - Dysregulated VLDL-TAG (very-low-density lipoprotein triacylglycerol) metabolism in obesity may account for hypertriacylglycerolaemia and increased cardiovascular disease. ω-3 FAEEs (omega-3 fatty acid ethyl esters) decrease plasma TAG and VLDL concentrations, but the mechanisms are not fully understood. In the present study, we carried out a 6-week randomized, placebo-controlled study to examine the effectof high-dose ω-3 FAEE supplementation (3.2 g/day) on the metabolism of VLDL-TAG in obese men using intravenous administration of d5-glycerol. We also explored the relationship of VLDL-TAG kinetics with the metabolism of VLDL-apo (apolipoprotein) B-100 and HDL (high-density lipoprotein)-apoA-I. VLDL-TAG isotopic enrichment was measured using gas chromatography-mass spectrometry. Kinetic parameters were derived using a multicompartmental model. Compared with placebo, ω-3 FAEE supplementation significantly lowered plasma concentrations of total (-14%, P0.05). Our results suggest that the TAG-lowering effect of ω-3 FAEEs is associated with the decreased VLDL-TAG secretion rate and hence lower plasma VLDL-TAG concentration in obesity. The changes in VLDL-TAG and apoB-100 kinetics are closely coupled. © The Authors Journal compilation 2013 Biochemical Society.
U2 - 10.1042/CS20120587
DO - 10.1042/CS20120587
M3 - Article
VL - 125
SP - 45
EP - 51
JO - Clinical Science
JF - Clinical Science
SN - 0143-5221
IS - 1
ER -