Olfactory episodic memory as a predictor of pre-clinical dementia in healthy aging older adults

Rasangi Seneviratne

doi:10.26182/knwh-g645

Olfactory episodic memory as a predictor of pre-clinical dementia in healthy aging older adults

Rasangi Seneviratne

Research output: Thesis › Doctoral Thesis

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Abstract

This thesis examined the predictive utility of olfactory episodic memory in the early detection of proxies for dementia using the newly developed Western Australia Olfactory Memory Test (WAOMT) in a sample of healthy aging older adults. The first study established WAOMT reliability and validity properties. In the second study, WAOMT recall predicted future changes in regional glucose metabolism in the pre-frontal cortex. In the final study, WAOMT performance was associated with baseline complex daily functioning, but not future daily functioning. In conclusion, the WAOMT is a reliable and valid tool to detect pre-clinical changes in healthy aging cohorts.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Weinborn, Michael, Supervisor Sohrabi, Hamid, Supervisor Badcock, David, Supervisor Martins, Ralph, Supervisor
Thesis sponsors	Australian Government Research Training Program
Award date	6 Jun 2022
DOIs	https://doi.org/10.26182/knwh-g645
Publication status	Unpublished - 2021

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10.26182/knwh-g645

THESIS - DOCTOR OF PHILOSOPHY - SENEVIRATNE, Rasangi Lakshitha - 2021
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Cite this

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title = "Olfactory episodic memory as a predictor of pre-clinical dementia in healthy aging older adults",

abstract = "This thesis examined the predictive utility of olfactory episodic memory in the early detection of proxies for dementia using the newly developed Western Australia Olfactory Memory Test (WAOMT) in a sample of healthy aging older adults. The first study established WAOMT reliability and validity properties. In the second study, WAOMT recall predicted future changes in regional glucose metabolism in the pre-frontal cortex. In the final study, WAOMT performance was associated with baseline complex daily functioning, but not future daily functioning. In conclusion, the WAOMT is a reliable and valid tool to detect pre-clinical changes in healthy aging cohorts.",

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AB - This thesis examined the predictive utility of olfactory episodic memory in the early detection of proxies for dementia using the newly developed Western Australia Olfactory Memory Test (WAOMT) in a sample of healthy aging older adults. The first study established WAOMT reliability and validity properties. In the second study, WAOMT recall predicted future changes in regional glucose metabolism in the pre-frontal cortex. In the final study, WAOMT performance was associated with baseline complex daily functioning, but not future daily functioning. In conclusion, the WAOMT is a reliable and valid tool to detect pre-clinical changes in healthy aging cohorts.

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KW - Health related to aging

KW - Memory

KW - Aging and Dementia

KW - Sensory processes, perception and performance

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Olfactory episodic memory as a predictor of pre-clinical dementia in healthy aging older adults

Abstract

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