Oestrogen replacement therapy may improve memory functioning in the absence of APOE E4

M.S. Burkhardt, Jonathan Foster, S.M. Laws, L.D. Baker, S. Craft, S.E. Gandy, B.G.A. Stuckey, R. Clarnette, D. Nolan, B. Hewson-Bower, Ralph Martins

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74 Citations (Scopus)

Abstract

There is currently intense controversy regarding the use of hormone replacement therapy (HRT) in postmenopausal women, in relation to its therapeutic efficacy in Alzheimer's disease (AD). It has been suggested that the benefits of HRT may be modified by apolipoprotein E (APOE) genotype (the major genetic risk factor for AD). Here we report the findings of the first study designed to systematically explore the interaction of (a) oestrogen replacement therapy (ERT) and (b) possession of an ℇ4 allele of APOE on specific elements of episodic learning and memory that are commonly used indices of age-related cognitive decline. This data represents a cross-sectional analysis of the interaction of ERT and APOE genotype on learning and memory in a cohort of 181 healthy postmenopausal women [ERT users (n = 101, mean age 65.40 ± 6.34); ERT non-users (n = 80, mean age 67.03 ± 6.80)] residing in Perth, Western Australia. The highest level of learning (trials 2–5; P <0.05) and memory (e.g. total number of items recalled; P <0.05) performance was observed in women taking ERT who were not carriers of the APOE ℇ4 allele. APOEℇ4 carriers receiving ERT performed no better on episodic memory testing than APOE ℇ4 carriers who were not receiving ERT. These cognitive differences related to genetic profile, were noted on both recall and recognition (P = 0.005) tests of memory. The findings have significance for evaluating whether and when ERT may be clinically indicated. Specifically, ERT may benefit the cognitive functioning of women not carrying the APOE ℇ4 allele. [ABSTRACT FROM AUTHOR]
Original languageEnglish
Pages (from-to)221-228
JournalJournal of Alzheimer's Disease
Volume6
Issue number3
Publication statusPublished - 2004

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