Occupational exposures and Parkinson's disease mortality in a prospective Dutch cohort

M. Brouwer, T. Koeman, P.A. Van Den Brandt, H. Kromhout, L.J. Schouten, Susan Peters, A. Huss, R. Vermeulen

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Abstract

© 2015, BMJ Publishing Group. All rights reserved. Objectives: We investigated the association between six occupational exposures (ie, pesticides, solvents, metals, diesel motor emissions (DME), extremely low frequency magnetic fields (ELF-MF) and electric shocks) and Parkinson's disease (PD) mortality in a large population-based prospective cohort study. Methods: The Netherlands Cohort Study on diet and cancer enrolled 58 279 men and 62 573 women aged 55-69 years in 1986. Participants were followed up for cause-specific mortality over 17.3 years, until December 2003, resulting in 402 male and 207 female PD deaths. Following a case-cohort design, a subcohort of 5 000 participants was randomly sampled from the complete cohort. Information on occupational history and potential confounders was collected at baseline. Job-exposure matrices were applied to assign occupational exposures. Associations with PD mortality were evaluated using Cox regression. Results: Among men, elevated HRs were observed for exposure to pesticides (eg, ever high exposed, HR 1.27, 95% CI 0.86 to 1.88) and ever high exposed to ELF-MF (HR 1.54, 95% CI 1.00 to 2.36). No association with exposure duration or trend in cumulative exposure was observed for any of the occupational exposures. Results among women were unstable due to small numbers of high-exposed women. Conclusions: Associations with PD mortality were observed for occupational exposure to pesticides and ELF-MF. However, the weight given to these findings is limited by the absence of a monotonic trend with either duration or cumulative exposure. No associations were found between PD mortality and occupational exposure to solvents, metals, DME or electric shocks.
Original languageEnglish
Pages (from-to)448-455
JournalOccupational and Environmental Medicine
Volume72
Issue number6
DOIs
Publication statusPublished - 2015

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Brouwer, M., Koeman, T., Van Den Brandt, P. A., Kromhout, H., Schouten, L. J., Peters, S., ... Vermeulen, R. (2015). Occupational exposures and Parkinson's disease mortality in a prospective Dutch cohort. Occupational and Environmental Medicine, 72(6), 448-455. https://doi.org/10.1136/oemed-2014-102209