Obstetric and neonatal outcomes of clozapine exposure in pregnancy: a consecutive case series

Thinh Nguyen, Jasmine Mordecai, Felice Watt, Jacqueline Frayne

Research output: Contribution to journalArticlepeer-review

8 Citations (Web of Science)

Abstract

Clozapine is an effective antipsychotic that can lead to symptom resolution and functional recovery in patients with schizophrenia. Its available pregnancy safety data remain limited, which presents a challenge for clinicians managing women of reproductive age on clozapine. We retrospectively studied a consecutive case series of nine pregnancies where there was clozapine exposure. Our case series demonstrates that pregnant women on clozapine treatment can remain stable psychiatrically, but are vulnerable obstetrically, with high rates of obesity and gestational diabetes. Their babies also have poor neonatal adjustment, often requiring neonatal resuscitation. Furthermore, we report on clozapine-related side effects, changes in clozapine levels during pregnancy as well as variation in foetal wellbeing monitoring. These findings have implications for pregnancy care for women taking clozapine and require further exploration.

Original languageEnglish
Pages (from-to)441–445
Number of pages5
JournalArchives of Women's Mental Health
Volume23
Issue number3
DOIs
Publication statusPublished - 1 Jun 2020

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