Nutritional diets accelerate amyloid beta metabolism and prevent the induction of chronic diseases and Alzheimer’s disease

Research output: Book/ReportBook

Abstract

The inductions of chronic diseases and neurodegeneration have become a major
concern in various countries in the developed and developing world. Central coordination and homeostasis of neuroendocrine systems and renin-angiotensin
systems (RAS) are influenced by external stressors, diet and lifestyles that lead to
abnormal nitric oxide and neural pathways, appetite dysregulationand organ
disease. The alteration in circadian photic signals in the neuroendocrine system
involve the hypothalamus and the suprachiasmatic nucleusthat are linked to
apelinergic dysregulation associated with appetite disorders and various organ
diseases. The peripheral sink amyloid beta hypothesisindicates that amyloid beta
(Aβ)is rapidly removed by the liver and chronic diseases are connected to
apelinergic dysfunction with abnormal amyloidogenic pathways that do not allow
the rapid hepatic metabolism of low n Aβ structures. Anti-aging processes cease as environmental pollutants induce senescent changes in various cells and tissues and do not allow the metabolism of various sizes of Aβ structures with the induction of cell suicide. Environmental pollutants associated with unhealthy nutritional habits increase xenobiotics in plasma andmay further promote neuroendocrine disease, kidney disease and non alcoholic fatty liver disease (NAFLD) with poor Aβmetabolism. Furthermore stress and unhealthy nutritional lifestyles increase oxidative stress with abnormal apelin and RAS regulation associated with poor nitric oxideandvascular Aβmetabolism with the acceleration ofneuroendocrine diseases that include obesity, diabetes, cardiovascular disease and neurodegenerative diseases.
Original languageEnglish
PublisherPhoton
Number of pages48
Volume1
Edition1
ISBN (Print)UBN: 015-A94510112017
Publication statusPublished - 1 Jul 2015

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