NUT Expression Is of Diagnostic Utility in the Distinction of Digital Papillary Carcinoma From Poroid Hidradenoma

Jean Iacobelli, Nathan T. Harvey, Nima Mesbah Ardakani, Lydia Ng, Henry Preston, Benjamin A. Wood

Research output: Contribution to journalArticlepeer-review

Abstract

ABSTRACT: The distinction between digital papillary adenocarcinoma (DPAC) and benign cutaneous adnexal tumors is clinically important and can be challenging. Poroid hidradenoma frequently occurs at acral sites and can show a number of histological features, which overlap with digital papillary adenocarcinoma. Recent work has shown that YAP1-NUTM1 fusions are frequent in poroid hidradenoma and are associated with nuclear protein in testis (NUT) expression by immunohistochemistry. We evaluated the expression of NUT-1 by immunohistochemistry in 4 cases of DPAC and 4 cases of poroid hidradenoma. Three of 4 cases of poroid hidradenoma showed strong NUT-1 expression, with no staining in any of the cases of DPAC. These results suggest that NUT-1 immunohistochemistry may be a useful additional tool in evaluating this differential diagnosis.

Original languageEnglish
Pages (from-to)98-100
Number of pages3
JournalThe American Journal of Dermatopathology
Volume46
Issue number2
Early online date2023
DOIs
Publication statusPublished - 1 Feb 2024

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