TY - JOUR
T1 - Nuclear bodies
T2 - news insights into structure and function
AU - Staněk, David
AU - Fox, A.
PY - 2017/6/1
Y1 - 2017/6/1
N2 - The cell nucleus contains a number of different dynamic bodies that are variously composed of proteins and generally, but not always, specific RNA molecules. Recent studies have revealed new understanding about nuclear body formation and function in different aspects of nuclear metabolism. Here, we focus on findings describing the role of nuclear bodies in the biogenesis of specific ribonucleoprotein complexes, processing of key mRNAs, and subnuclear sequestration of protein factors. We highlight how nuclear bodies are involved in stress responses, innate immunity and tumorigenesis. We further review organization of nuclear bodies and principles that govern their assembly, highlighting the pivotal role of scaffolding noncoding RNAs, and liquid–liquid phase separation, which are transforming our picture of nuclear body formation.
AB - The cell nucleus contains a number of different dynamic bodies that are variously composed of proteins and generally, but not always, specific RNA molecules. Recent studies have revealed new understanding about nuclear body formation and function in different aspects of nuclear metabolism. Here, we focus on findings describing the role of nuclear bodies in the biogenesis of specific ribonucleoprotein complexes, processing of key mRNAs, and subnuclear sequestration of protein factors. We highlight how nuclear bodies are involved in stress responses, innate immunity and tumorigenesis. We further review organization of nuclear bodies and principles that govern their assembly, highlighting the pivotal role of scaffolding noncoding RNAs, and liquid–liquid phase separation, which are transforming our picture of nuclear body formation.
UR - http://www.scopus.com/inward/record.url?scp=85020016412&partnerID=8YFLogxK
U2 - 10.1016/j.ceb.2017.05.001
DO - 10.1016/j.ceb.2017.05.001
M3 - Article
C2 - 28577509
AN - SCOPUS:85020016412
SN - 0955-0674
VL - 46
SP - 94
EP - 101
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
ER -