Nuclear bodies: news insights into structure and function

David Staněk, A. Fox

Research output: Contribution to journalArticlepeer-review

79 Citations (Scopus)

Abstract

The cell nucleus contains a number of different dynamic bodies that are variously composed of proteins and generally, but not always, specific RNA molecules. Recent studies have revealed new understanding about nuclear body formation and function in different aspects of nuclear metabolism. Here, we focus on findings describing the role of nuclear bodies in the biogenesis of specific ribonucleoprotein complexes, processing of key mRNAs, and subnuclear sequestration of protein factors. We highlight how nuclear bodies are involved in stress responses, innate immunity and tumorigenesis. We further review organization of nuclear bodies and principles that govern their assembly, highlighting the pivotal role of scaffolding noncoding RNAs, and liquid–liquid phase separation, which are transforming our picture of nuclear body formation.

Original languageEnglish
Pages (from-to)94-101
Number of pages8
JournalCurrent Opinion in Cell Biology
Volume46
DOIs
Publication statusPublished - 1 Jun 2017

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