Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 1882-1884 |
| Journal | NeuroReport |
| Volume | 5 |
| Issue number | 15 |
| DOIs | |
| Publication status | Published - 1994 |
Fingerprint
Cite this
}
NT-4/5 reduces naturally occurring retinal ganglion cell death in neonatal rats. / Cui, Q.; Harvey, Alan.
In: NeuroReport, Vol. 5, No. 15, 1994, p. 1882-1884.Research output: Contribution to journal › Article
TY - JOUR
T1 - NT-4/5 reduces naturally occurring retinal ganglion cell death in neonatal rats
AU - Cui, Q.
AU - Harvey, Alan
PY - 1994
Y1 - 1994
N2 - THE retrograde nucleophilic tracer diamidino yellow (DY) was injected into the left superior colliculi of 2-day-old rats. Two days later, right eyes were injected with either neurotrophin NT-4/5, cycloheximide (CHX), MK-801 and DNQX (glutamate receptor antagonists), or saline. Almost all rats were perfused 6-7 h later and the numbers of normal and pyknotic DY-labelled retinal ganglion cells (RGCs) were determined from retinal whole mounts. In controls (no eye injection) the proportion of pyknotic RGCs was 1.04%. This level of naturally occurring death was significantly reduced after injection of NT-4/5 (0.34%); normal RGC density was also higher in this group. RGC pyknosis was increased after saline (1.21%), MK-801/DNQX (1.22%) or CHX (1.48%) injections but only in the latter case was the increase significantly greater than control.
AB - THE retrograde nucleophilic tracer diamidino yellow (DY) was injected into the left superior colliculi of 2-day-old rats. Two days later, right eyes were injected with either neurotrophin NT-4/5, cycloheximide (CHX), MK-801 and DNQX (glutamate receptor antagonists), or saline. Almost all rats were perfused 6-7 h later and the numbers of normal and pyknotic DY-labelled retinal ganglion cells (RGCs) were determined from retinal whole mounts. In controls (no eye injection) the proportion of pyknotic RGCs was 1.04%. This level of naturally occurring death was significantly reduced after injection of NT-4/5 (0.34%); normal RGC density was also higher in this group. RGC pyknosis was increased after saline (1.21%), MK-801/DNQX (1.22%) or CHX (1.48%) injections but only in the latter case was the increase significantly greater than control.
U2 - 10.1097/00001756-199410000-00010
DO - 10.1097/00001756-199410000-00010
M3 - Article
VL - 5
SP - 1882
EP - 1884
JO - NeuroReport: for rapid communication of neuroscience research
JF - NeuroReport: for rapid communication of neuroscience research
SN - 0959-4965
IS - 15
ER -