Abstract
THE retrograde nucleophilic tracer diamidino yellow (DY) was injected into the left superior colliculi of 2-day-old rats. Two days later, right eyes were injected with either neurotrophin NT-4/5, cycloheximide (CHX), MK-801 and DNQX (glutamate receptor antagonists), or saline. Almost all rats were perfused 6-7 h later and the numbers of normal and pyknotic DY-labelled retinal ganglion cells (RGCs) were determined from retinal whole mounts. In controls (no eye injection) the proportion of pyknotic RGCs was 1.04%. This level of naturally occurring death was significantly reduced after injection of NT-4/5 (0.34%); normal RGC density was also higher in this group. RGC pyknosis was increased after saline (1.21%), MK-801/DNQX (1.22%) or CHX (1.48%) injections but only in the latter case was the increase significantly greater than control.
| Original language | English |
|---|---|
| Pages (from-to) | 1882-1884 |
| Journal | NeuroReport |
| Volume | 5 |
| Issue number | 15 |
| DOIs | |
| Publication status | Published - 1994 |
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Cui, Q., & Harvey, A. (1994). NT-4/5 reduces naturally occurring retinal ganglion cell death in neonatal rats. NeuroReport, 5(15), 1882-1884. https://doi.org/10.1097/00001756-199410000-00010