@phdthesis{fbda6644cc564aba8f890a581b3bb5de,
title = "Novel strategies to improve cancer immunotherapy",
abstract = "Immunotherapies are revolutionising outcomes for cancer patients; however, the majority of patients do not respond to therapy and so further improvements are necessary. This thesis seeks to explore strategies and identify novel targets that may synergise with current immunotherapies to improve anti-tumour activity, with a focus on promoting CD8+ T cell immunity. To achieve this, we utilised sophisticated preclinical models and embraced disruptive sequencing technologies. This led to the identification of several novel drugs with potent anti-cancer activity. Ultimately, it is hoped that these identified targets will synergise with existing immunotherapies in the clinic to improve outcomes for cancer patients.",
keywords = "tumor immunology, immunotherapy, XCR1+ dendritic cells, CD8+ T cells, Type I interferon",
author = "Katherine Audsley",
year = "2022",
doi = "10.26182/qjqm-zm19",
language = "English",
school = "The University of Western Australia",
}