Novel strategies to improve cancer immunotherapy

Katherine Audsley

Research output: ThesisDoctoral Thesis

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Abstract

Immunotherapies are revolutionising outcomes for cancer patients; however, the majority of patients do not respond to therapy and so further improvements are necessary. This thesis seeks to explore strategies and identify novel targets that may synergise with current immunotherapies to improve anti-tumour activity, with a focus on promoting CD8+ T cell immunity. To achieve this, we utilised sophisticated preclinical models and embraced disruptive sequencing technologies. This led to the identification of several novel drugs with potent anti-cancer activity. Ultimately, it is hoped that these identified targets will synergise with existing immunotherapies in the clinic to improve outcomes for cancer patients.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Fear, Vanessa, Supervisor
  • McDonnell, Alison, Supervisor
  • Foley, Bree, Supervisor
  • Fernandez, Sonia, Supervisor
  • Waithman, Jason, Supervisor
  • Bosco, Anthony, Supervisor
Thesis sponsors
Award date1 Feb 2023
DOIs
Publication statusUnpublished - 2022

Embargo information

  • Embargoed from 30/01/2023 to 23/01/2025. Made publicly available on 23/01/2025.

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