Novel strategies for the design of cardiac scaffolds using melt electrowriting

Research output: ThesisDoctoral Thesis

Abstract

Melt electrowetting (MEW) is a promising advanced manufacturing technology for biomedical applications, especially cardiovascular disease (CVD). While MEW has the ability to incorporate specific microscale features, design concepts and methodologies implemented have been limited. In the context of heart valves and myocardial patches, this thesis advances the conceptual frameworks and methodologies used to design MEW scaffolds. Microscopy investigations into native tissue, coupled with the development of a universal G-code generator enabled the design of complex functional biomimetic MEW heart valve scaffolds, while gradient MEW scaffolds were able to regulate cardiomyocyte contraction direction, matching native myocardium. Thus, advancing MEW's potential in treating CVD.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Juan Pardo, Elena, Supervisor
  • Doyle, Barry, Supervisor
  • Jansen, Shirley, Supervisor
  • Ihdayhid, Abdul, Supervisor
Thesis sponsors
Award date7 Oct 2024
DOIs
Publication statusUnpublished - 2024

Embargo information

  • Embargoed from 07/10/2024 to 01/10/2026. Will become publicly available on 01/10/2026

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