Novel behavioural approaches and implementation science for mitigating genetic risk of cardiovascular disease due to elevated lipoprotein(a)

Barbara Mullan, Dick Chan, Jessica Charlesworth, Joanna Moullin, Carl Schultz, Gerald F Watts

Research output: Contribution to journalReview articlepeer-review

4 Citations (Scopus)

Abstract

PURPOSE OF REVIEW: Elevated lipoprotein(a) [Lp(a)] is a genetic trait that indicates higher risk of atherosclerotic cardiovascular disease (ASCVD). We review novel strategies to mitigate behavioural risk-factors in this genetic condition.

RECENT FINDINGS: Pharmacological and biological interventions are available for lowering Lp(a). However, the acceptability and feasibility of these approaches are questionable due to cost and lack of clinical evidence for their efficacy. A number of low-cost, minimal patient contact interventions are available for modifying behavioural risk-factors that are associated with increased risk of ASCVD familial hypercholesterolaemia and diabetes. These include lifestyle interventions designed to improve diet and physical activity. These interventions may be particularly important among individuals with elevated Lp(a) to manage their higher risk of diabetes and ASCVD. The following article outlines recent research that has examined such low-cost, minimal patient contact interventions.

SUMMARY: The current research indicated that such interventions, which are grounded in psychological theory, can assist individuals to improve their diet and physical activity. These findings have implications for developing and implementing similar interventions for individuals with elevated Lp(a), so as to assist in reducing behavioural risk-factors associated with ASCVD.

Original languageEnglish
Pages (from-to)174-180
Number of pages7
JournalCurrent Opinion in Endocrinology, Diabetes and Obesity
Volume28
Issue number2
DOIs
Publication statusPublished - 1 Apr 2021

Fingerprint

Dive into the research topics of 'Novel behavioural approaches and implementation science for mitigating genetic risk of cardiovascular disease due to elevated lipoprotein(a)'. Together they form a unique fingerprint.

Cite this