Notch-induced transcription factors are predictive of survival and 5-fluorouracil response in colorectal cancer patients

P.A. Candy; Michael Phillips; Andrew Redfern; Shane Colley; Andrew Davidson; Lisa Stuart; B.A. Wood; N. Zeps; Peter Leedman

doi:10.1038/bjc.2013.431

Notch-induced transcription factors are predictive of survival and 5-fluorouracil response in colorectal cancer patients

P.A. Candy, Michael Phillips, Andrew Redfern, Shane Colley, Andrew Davidson, Lisa Stuart, B.A. Wood, N. Zeps, Peter Leedman

Research output: Contribution to journal › Article › peer-review

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Abstract

Background: The purpose of this study was to evaluate the expression of Notch-induced transcription factors (NTFs) HEY1, HES1 and SOX9 in colorectal cancer (CRC) patients to determine their clinicopathologic and prognostic significance. Methods: Levels of HEY1, HES1 and SOX9 protein were measured by immunohistochemistry in a nonmalignant and malignant tissue microarray of 441 CRC patients, and the findings correlated with pathologic, molecular and clinical variables. Results: The NTFs HEY1, HES1 and SOX9 were overexpressed in tumours relative to colonic mucosa (OR=3.44, P

Original language	English
Pages (from-to)	1023-1030
Journal	British Journal of Cancer
Volume	109
Issue number	4
DOIs	https://doi.org/10.1038/bjc.2013.431
Publication status	Published - 2013

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10.1038/bjc.2013.431

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title = "Notch-induced transcription factors are predictive of survival and 5-fluorouracil response in colorectal cancer patients",

abstract = "Background: The purpose of this study was to evaluate the expression of Notch-induced transcription factors (NTFs) HEY1, HES1 and SOX9 in colorectal cancer (CRC) patients to determine their clinicopathologic and prognostic significance. Methods: Levels of HEY1, HES1 and SOX9 protein were measured by immunohistochemistry in a nonmalignant and malignant tissue microarray of 441 CRC patients, and the findings correlated with pathologic, molecular and clinical variables. Results: The NTFs HEY1, HES1 and SOX9 were overexpressed in tumours relative to colonic mucosa (OR=3.44, P",

author = "P.A. Candy and Michael Phillips and Andrew Redfern and Shane Colley and Andrew Davidson and Lisa Stuart and B.A. Wood and N. Zeps and Peter Leedman",

year = "2013",

doi = "10.1038/bjc.2013.431",

language = "English",

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journal = "British Journal of Cancer",

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T1 - Notch-induced transcription factors are predictive of survival and 5-fluorouracil response in colorectal cancer patients

AU - Candy, P.A.

AU - Phillips, Michael

AU - Redfern, Andrew

AU - Colley, Shane

AU - Davidson, Andrew

AU - Stuart, Lisa

AU - Wood, B.A.

AU - Zeps, N.

AU - Leedman, Peter

PY - 2013

Y1 - 2013

N2 - Background: The purpose of this study was to evaluate the expression of Notch-induced transcription factors (NTFs) HEY1, HES1 and SOX9 in colorectal cancer (CRC) patients to determine their clinicopathologic and prognostic significance. Methods: Levels of HEY1, HES1 and SOX9 protein were measured by immunohistochemistry in a nonmalignant and malignant tissue microarray of 441 CRC patients, and the findings correlated with pathologic, molecular and clinical variables. Results: The NTFs HEY1, HES1 and SOX9 were overexpressed in tumours relative to colonic mucosa (OR=3.44, P

AB - Background: The purpose of this study was to evaluate the expression of Notch-induced transcription factors (NTFs) HEY1, HES1 and SOX9 in colorectal cancer (CRC) patients to determine their clinicopathologic and prognostic significance. Methods: Levels of HEY1, HES1 and SOX9 protein were measured by immunohistochemistry in a nonmalignant and malignant tissue microarray of 441 CRC patients, and the findings correlated with pathologic, molecular and clinical variables. Results: The NTFs HEY1, HES1 and SOX9 were overexpressed in tumours relative to colonic mucosa (OR=3.44, P

U2 - 10.1038/bjc.2013.431

DO - 10.1038/bjc.2013.431

M3 - Article

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VL - 109

SP - 1023

EP - 1030

JO - British Journal of Cancer

JF - British Journal of Cancer

SN - 0007-0920

IS - 4

ER -

Notch-induced transcription factors are predictive of survival and 5-fluorouracil response in colorectal cancer patients

Abstract

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