Non-culture neisseria gonorrhoeae molecular penicillinase production surveillance demonstrates the long-term success of empirical dual therapy and informs gonorrhoea management guidelines in a highly endemic setting

David Speers, R.E. Fisk, N. Goire, D.B. Mak

    Research output: Contribution to journalArticle

    17 Citations (Scopus)

    Abstract

    Objectives: Unlike most of the world, penicillin resistance in Neisseria gonorrhoeae from remote regions of Western Australia (WA) with high gonorrhoea notification rates has not increased despite many years of empirical oral therapy. With the advent of non-culture molecular diagnosis of gonorrhoea and the consequent decline in culture-based susceptibility, it is imperative to ensure the ongoing reliability of combination oral azithromycin, amoxicillin and probenecid for uncomplicated gonorrhoea in this setting. PCR-based non-culture N. gonorrhoeae antimicrobial resistance surveillance for penicillinase production was therefore employed. Methods: Genital and non-genital specimens that were PCR-positive for N. gonorrhoeae were assessed for penicillinase production by detection of the N. gonorrhoeae TEM-1 plasmid using specific real-time PCR. Results: In remote regions ofWAwhere gonorrhoea is highly endemic,
    Original languageEnglish
    Pages (from-to)1243-1247
    JournalJournal of Antimicrobial Chemotherapy
    Volume69
    Issue number5
    DOIs
    Publication statusPublished - 2014

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