No Major Schizophrenia Locus Detected on Chromosome 1q in a Large Multicenter Sample

D.F. Levinson, P.A. Holmans, C. Laurent, B. Riley, A.E. Pulver, P.V. Gejman, Sibylle Schwab, N.M. Williams, M.J. Owen, Dieter Wildenauer, A.R. Sanders, G. Nestadt, B.J. Mowry, B. Wormley, S. Bauche, S. Soubigou, R. Ribble, D.A. Nertney, K.Y. Liang, L. MartinolichW. Maier, N. Norton, H. Williams, M. Albus, E.B. Carpenter, N. Demarchi, K.R. Ewen-White, D. Walsh, M. Jay, J.F. Deleuze, F.A. O'Neill, G. Papadimitriou, A. Weilbaecher, B. Lerer, M.C. O'Donovan, D. Dikeos, J.M. Silverman, K.S. Kendler, J. Mallet, R.R. Crowe, M. Walters

    Research output: Contribution to journalArticlepeer-review

    72 Citations (Scopus)

    Abstract

    Reports of substantial evidence for genetic linkage of schizophrenia to chromosome 1q were evaluated by genotyping 16 DNA markers across 107 centimorgans of this chromosome in a multicenter sample of 779 informative schizophrenia pedigrees. No significant evidence was observed for such linkage, nor for heterogeneity in allele sharing among the eight individual samples. Separate analyses of European-origin families, recessive models of inheritance, and families with larger numbers of affected cases also failed to produce significant evidence for linkage. If schizophrenia susceptibility genes are present on chromosome 1q, their population-wide genetic effects are likely to be small.
    Original languageEnglish
    Pages (from-to)739-741
    JournalScience
    Volume296
    DOIs
    Publication statusPublished - 2002

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