No Associations Between Regular Use of Proton Pump Inhibitors and Risk of All-Cause and Cause-Specific Mortality: A Population-Based Cohort of 0.44 Million Participants

Qiangsheng He; Bin Xia; Wenbo Meng; Die Fan; Zi Chong Kuo; Junjie Huang; Xiwen Qin; Huachun Zou; Yulong He; Changhua Zhang; Shuo Fang; Yihang Pan; Man Yang; Jinqiu Yuan

doi:10.14309/ajg.0000000000001377

No Associations Between Regular Use of Proton Pump Inhibitors and Risk of All-Cause and Cause-Specific Mortality: A Population-Based Cohort of 0.44 Million Participants

Qiangsheng He, Bin Xia, Wenbo Meng, Die Fan, Zi Chong Kuo, Junjie Huang, Xiwen Qin, Huachun Zou, Yulong He, Changhua Zhang, Shuo Fang, Yihang Pan, Man Yang, Jinqiu Yuan

School of Population and Global Health

Research output: Contribution to journal › Article › peer-review

14 Citations (Web of Science)

Abstract

INTRODUCTION: The association between proton pump inhibitors' (PPIs) use and mortality remains unclear. METHODS: This was a prospective analysis of 440,840 UK residents and 13,154 deaths. We evaluated the associations with multivariate Cox regression. RESULTS: After adjusting for confounders, such as over health status and longstanding diseases, the regular use of PPIs was not associated with an increased risk of all-cause mortality and mortality due to neoplasms, circulatory system diseases, respiratory system diseases, digestive system diseases, external causes, and other causes. DISCUSSION: Regular use of PPIs was not associated with an increased risk of all-cause and cause-specific mortality.

Original language	English
Pages (from-to)	2286-2291
Number of pages	6
Journal	The American Journal of Gastroenterology
Volume	116
Issue number	11
DOIs	https://doi.org/10.14309/ajg.0000000000001377
Publication status	Published - 1 Nov 2021

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He, Q., Xia, B., Meng, W., Fan, D., Kuo, Z. C., Huang, J., Qin, X., Zou, H., He, Y., Zhang, C., Fang, S., Pan, Y., Yang, M., & Yuan, J. (2021). No Associations Between Regular Use of Proton Pump Inhibitors and Risk of All-Cause and Cause-Specific Mortality: A Population-Based Cohort of 0.44 Million Participants. The American Journal of Gastroenterology, 116(11), 2286-2291. https://doi.org/10.14309/ajg.0000000000001377

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title = "No Associations Between Regular Use of Proton Pump Inhibitors and Risk of All-Cause and Cause-Specific Mortality: A Population-Based Cohort of 0.44 Million Participants",

abstract = "INTRODUCTION: The association between proton pump inhibitors' (PPIs) use and mortality remains unclear. METHODS: This was a prospective analysis of 440,840 UK residents and 13,154 deaths. We evaluated the associations with multivariate Cox regression. RESULTS: After adjusting for confounders, such as over health status and longstanding diseases, the regular use of PPIs was not associated with an increased risk of all-cause mortality and mortality due to neoplasms, circulatory system diseases, respiratory system diseases, digestive system diseases, external causes, and other causes. DISCUSSION: Regular use of PPIs was not associated with an increased risk of all-cause and cause-specific mortality.",

author = "Qiangsheng He and Bin Xia and Wenbo Meng and Die Fan and Kuo, {Zi Chong} and Junjie Huang and Xiwen Qin and Huachun Zou and Yulong He and Changhua Zhang and Shuo Fang and Yihang Pan and Man Yang and Jinqiu Yuan",

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doi = "10.14309/ajg.0000000000001377",

language = "English",

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He, Q, Xia, B, Meng, W, Fan, D, Kuo, ZC, Huang, J, Qin, X, Zou, H, He, Y, Zhang, C, Fang, S, Pan, Y, Yang, M & Yuan, J 2021, 'No Associations Between Regular Use of Proton Pump Inhibitors and Risk of All-Cause and Cause-Specific Mortality: A Population-Based Cohort of 0.44 Million Participants', The American Journal of Gastroenterology, vol. 116, no. 11, pp. 2286-2291. https://doi.org/10.14309/ajg.0000000000001377

No Associations Between Regular Use of Proton Pump Inhibitors and Risk of All-Cause and Cause-Specific Mortality: A Population-Based Cohort of 0.44 Million Participants. / He, Qiangsheng; Xia, Bin; Meng, Wenbo et al.
In: The American Journal of Gastroenterology, Vol. 116, No. 11, 01.11.2021, p. 2286-2291.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - No Associations Between Regular Use of Proton Pump Inhibitors and Risk of All-Cause and Cause-Specific Mortality

T2 - A Population-Based Cohort of 0.44 Million Participants

AU - He, Qiangsheng

AU - Xia, Bin

AU - Meng, Wenbo

AU - Fan, Die

AU - Kuo, Zi Chong

AU - Huang, Junjie

AU - Qin, Xiwen

AU - Zou, Huachun

AU - He, Yulong

AU - Zhang, Changhua

AU - Fang, Shuo

AU - Pan, Yihang

AU - Yang, Man

AU - Yuan, Jinqiu

PY - 2021/11/1

Y1 - 2021/11/1

N2 - INTRODUCTION: The association between proton pump inhibitors' (PPIs) use and mortality remains unclear. METHODS: This was a prospective analysis of 440,840 UK residents and 13,154 deaths. We evaluated the associations with multivariate Cox regression. RESULTS: After adjusting for confounders, such as over health status and longstanding diseases, the regular use of PPIs was not associated with an increased risk of all-cause mortality and mortality due to neoplasms, circulatory system diseases, respiratory system diseases, digestive system diseases, external causes, and other causes. DISCUSSION: Regular use of PPIs was not associated with an increased risk of all-cause and cause-specific mortality.

AB - INTRODUCTION: The association between proton pump inhibitors' (PPIs) use and mortality remains unclear. METHODS: This was a prospective analysis of 440,840 UK residents and 13,154 deaths. We evaluated the associations with multivariate Cox regression. RESULTS: After adjusting for confounders, such as over health status and longstanding diseases, the regular use of PPIs was not associated with an increased risk of all-cause mortality and mortality due to neoplasms, circulatory system diseases, respiratory system diseases, digestive system diseases, external causes, and other causes. DISCUSSION: Regular use of PPIs was not associated with an increased risk of all-cause and cause-specific mortality.

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JO - The American Journal of Gastroenterology

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ER -

No Associations Between Regular Use of Proton Pump Inhibitors and Risk of All-Cause and Cause-Specific Mortality: A Population-Based Cohort of 0.44 Million Participants

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