TY - JOUR
T1 - No association between serum platelet derived growth factor, platelet size, and regression of coronary artery disease
AU - Bath, P.M.W.
AU - Blann, A.
AU - Watts, Gerald
PY - 1994
Y1 - 1994
N2 - Platelets are involved in atherogenesis, partly through the release of smooth muscle cell mitogens and chemoattractants such as platelet-derived growth factor (PDGF). The St Thomas' Atherosclerosis Regression Study (STARS) demonstrated that a cholesterol-lowering diet induced angiographic regression of coronary artery disease in 74 men. Serum PDGF concentrations were not different at the end of the study between patients randomised to receive diet, with or without cholestyramine: usual care (UC) median 53.6 pM (interquartile range 15.3), diet (D) 60.0 pM (29.7), diet and cholestyramine (DC) 51.5 pM (13.0), 2p = 0.23. Similarly, mean platelet volume (MPV), a marker of platelet function, did not differ between the three groups: UC 8.0 fl (1.1), D 8.6 fl (0.8), DC 9.0 fl (1.4), 2p = 0.16. PDGF concentrations and MPV did not correlate with lipid concentrations or angiographic indices of regression. These findings suggest that platelet function, as measured by PDGF and MPV, does not change during, or contribute to, dietary-induced regression of coronary artery disease.
AB - Platelets are involved in atherogenesis, partly through the release of smooth muscle cell mitogens and chemoattractants such as platelet-derived growth factor (PDGF). The St Thomas' Atherosclerosis Regression Study (STARS) demonstrated that a cholesterol-lowering diet induced angiographic regression of coronary artery disease in 74 men. Serum PDGF concentrations were not different at the end of the study between patients randomised to receive diet, with or without cholestyramine: usual care (UC) median 53.6 pM (interquartile range 15.3), diet (D) 60.0 pM (29.7), diet and cholestyramine (DC) 51.5 pM (13.0), 2p = 0.23. Similarly, mean platelet volume (MPV), a marker of platelet function, did not differ between the three groups: UC 8.0 fl (1.1), D 8.6 fl (0.8), DC 9.0 fl (1.4), 2p = 0.16. PDGF concentrations and MPV did not correlate with lipid concentrations or angiographic indices of regression. These findings suggest that platelet function, as measured by PDGF and MPV, does not change during, or contribute to, dietary-induced regression of coronary artery disease.
U2 - 10.3109/09537109409005525
DO - 10.3109/09537109409005525
M3 - Article
VL - 5
SP - 135
EP - 138
JO - Platelets
JF - Platelets
SN - 0953-7104
ER -