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Abstract
The FOXP2 gene is hypothesised to be involved in schizophrenia by affecting speech and language development. Associations between common single nucleotide polymorphisms (SNPs) in FOXP2 and language have been inconsistent. We tested five previously associated SNPs for association with language in the Western Australian Family Study of Schizophrenia (n = 709, including n = 333 with schizophrenia/spectrum disorder) and found no significant associations. When we included all common FOXP2 variants, one SNP (rs2189008) was nominally associated with language. This is the most comprehensive analysis to date and indicates that common variants in FOXP2 do not play a major role in speech and language development in a clinical family sample.
Original language | English |
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Pages (from-to) | 590-597 |
Number of pages | 8 |
Journal | Psychiatry Research |
Volume | 271 |
DOIs | |
Publication status | Published - Jan 2019 |
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Dive into the research topics of 'No association between common genetic variation in FOXP2 and language impairment in schizophrenia'. Together they form a unique fingerprint.Projects
- 1 Finished
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Schizophrenia under the genomic lens: next generation sequencing of Western Australian families with schizophrenia
Jablensky, A. (Investigator 01), Moses, E. (Investigator 02), McCarthy, N. (Investigator 03), Melton, P. (Investigator 04), Morgan, V. (Investigator 05), Badcock, J. (Investigator 06) & Waters, F. (Investigator 07)
NHMRC National Health and Medical Research Council
1/01/14 → 31/12/16
Project: Research