No association between common genetic variation in FOXP2 and language impairment in schizophrenia

Research output: Contribution to journalArticle

Abstract

The FOXP2 gene is hypothesised to be involved in schizophrenia by affecting speech and language development. Associations between common single nucleotide polymorphisms (SNPs) in FOXP2 and language have been inconsistent. We tested five previously associated SNPs for association with language in the Western Australian Family Study of Schizophrenia (n = 709, including n = 333 with schizophrenia/spectrum disorder) and found no significant associations. When we included all common FOXP2 variants, one SNP (rs2189008) was nominally associated with language. This is the most comprehensive analysis to date and indicates that common variants in FOXP2 do not play a major role in speech and language development in a clinical family sample.

Original languageEnglish
Pages (from-to)590-597
Number of pages8
JournalPsychiatry Research
Volume271
DOIs
Publication statusPublished - Jan 2019

Cite this

@article{27368577838840d6824e4d9398da0675,
title = "No association between common genetic variation in FOXP2 and language impairment in schizophrenia",
abstract = "The FOXP2 gene is hypothesised to be involved in schizophrenia by affecting speech and language development. Associations between common single nucleotide polymorphisms (SNPs) in FOXP2 and language have been inconsistent. We tested five previously associated SNPs for association with language in the Western Australian Family Study of Schizophrenia (n = 709, including n = 333 with schizophrenia/spectrum disorder) and found no significant associations. When we included all common FOXP2 variants, one SNP (rs2189008) was nominally associated with language. This is the most comprehensive analysis to date and indicates that common variants in FOXP2 do not play a major role in speech and language development in a clinical family sample.",
keywords = "GENOME-WIDE ASSOCIATION, SCHIZOTYPAL PERSONALITY, SEVERE SPEECH, POLYMORPHISMS, HALLUCINATIONS, VARIANT",
author = "McCarthy, {Nina S.} and Clark, {Melanie L.} and Assen Jablensky and Badcock, {Johanna C.}",
year = "2019",
month = "1",
doi = "10.1016/j.psychres.2018.12.016",
language = "English",
volume = "271",
pages = "590--597",
journal = "Psychiatry Research",
issn = "0165-1781",
publisher = "Elsevier",

}

TY - JOUR

T1 - No association between common genetic variation in FOXP2 and language impairment in schizophrenia

AU - McCarthy, Nina S.

AU - Clark, Melanie L.

AU - Jablensky, Assen

AU - Badcock, Johanna C.

PY - 2019/1

Y1 - 2019/1

N2 - The FOXP2 gene is hypothesised to be involved in schizophrenia by affecting speech and language development. Associations between common single nucleotide polymorphisms (SNPs) in FOXP2 and language have been inconsistent. We tested five previously associated SNPs for association with language in the Western Australian Family Study of Schizophrenia (n = 709, including n = 333 with schizophrenia/spectrum disorder) and found no significant associations. When we included all common FOXP2 variants, one SNP (rs2189008) was nominally associated with language. This is the most comprehensive analysis to date and indicates that common variants in FOXP2 do not play a major role in speech and language development in a clinical family sample.

AB - The FOXP2 gene is hypothesised to be involved in schizophrenia by affecting speech and language development. Associations between common single nucleotide polymorphisms (SNPs) in FOXP2 and language have been inconsistent. We tested five previously associated SNPs for association with language in the Western Australian Family Study of Schizophrenia (n = 709, including n = 333 with schizophrenia/spectrum disorder) and found no significant associations. When we included all common FOXP2 variants, one SNP (rs2189008) was nominally associated with language. This is the most comprehensive analysis to date and indicates that common variants in FOXP2 do not play a major role in speech and language development in a clinical family sample.

KW - GENOME-WIDE ASSOCIATION

KW - SCHIZOTYPAL PERSONALITY

KW - SEVERE SPEECH

KW - POLYMORPHISMS

KW - HALLUCINATIONS

KW - VARIANT

U2 - 10.1016/j.psychres.2018.12.016

DO - 10.1016/j.psychres.2018.12.016

M3 - Article

VL - 271

SP - 590

EP - 597

JO - Psychiatry Research

JF - Psychiatry Research

SN - 0165-1781

ER -