NMOSD acute attack: Understanding, treatment and innovative treatment prospect

Xiaoyu Ma; Allan G. Kermode; Xueqiang Hu; Wei Qiu

doi:10.1016/j.jneuroim.2020.577387

NMOSD acute attack: Understanding, treatment and innovative treatment prospect

Xiaoyu Ma, Allan G. Kermode, Xueqiang Hu, Wei Qiu

Centre for Neuromuscular & Neurological Disorders

Research output: Contribution to journal › Review article

Abstract

Neuromyelitis optica spectrum disorder (NMOSD) is a group of severe inflammatory demyelinating disorders of the central nervous system that involves the optic nerve and spinal cord. Currently the therapeutic options for an acute attack in NMOSD are limited and rarely characterized in clinical studies. This review discussed the overall characteristics of acute attack of NMOSD, related risk factor, prognosis and management. Considering the huge unmet needs and the emergence of new therapeutic targets, we also reviewed innovative treatments that might alleviate attack damage, along with the challenges to evaluate new drug for acute attack in NMOSD.

Original language	English
Article number	577387
Journal	Journal of Neuroimmunology
Volume	348
DOIs	https://doi.org/10.1016/j.jneuroim.2020.577387
Publication status	Published - 15 Nov 2020

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10.1016/j.jneuroim.2020.577387

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Ma, X., Kermode, A. G., Hu, X., & Qiu, W. (2020). NMOSD acute attack: Understanding, treatment and innovative treatment prospect. Journal of Neuroimmunology, 348, [577387]. https://doi.org/10.1016/j.jneuroim.2020.577387

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abstract = "Neuromyelitis optica spectrum disorder (NMOSD) is a group of severe inflammatory demyelinating disorders of the central nervous system that involves the optic nerve and spinal cord. Currently the therapeutic options for an acute attack in NMOSD are limited and rarely characterized in clinical studies. This review discussed the overall characteristics of acute attack of NMOSD, related risk factor, prognosis and management. Considering the huge unmet needs and the emergence of new therapeutic targets, we also reviewed innovative treatments that might alleviate attack damage, along with the challenges to evaluate new drug for acute attack in NMOSD.",

keywords = "Acute attack, Innovative treatment, Neuromyelitis optica spectrum disorder, Risk factor, Severe attack",

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AB - Neuromyelitis optica spectrum disorder (NMOSD) is a group of severe inflammatory demyelinating disorders of the central nervous system that involves the optic nerve and spinal cord. Currently the therapeutic options for an acute attack in NMOSD are limited and rarely characterized in clinical studies. This review discussed the overall characteristics of acute attack of NMOSD, related risk factor, prognosis and management. Considering the huge unmet needs and the emergence of new therapeutic targets, we also reviewed innovative treatments that might alleviate attack damage, along with the challenges to evaluate new drug for acute attack in NMOSD.

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