TY - JOUR
T1 - Nitric oxide, malaria and African children
AU - Clark, I.
AU - Rockett, K.A.
AU - Burgner, David
PY - 2003
Y1 - 2003
N2 - The unresolved and complex relationship between nitric oxide and falciparum malaria is reflected in recent genetic and immunohistochemical studies in African children. Different genetic associations, perhaps geographically distinctive, are seen between genetic variants of the inducible nitric oxide gene and various disease manifestations in African populations. The picture might not be complete without considering the emerging roles of carbon monoxide, another endogenous gaseous mediator with similar effects to those of nitric oxide. Only when genetic comparisons from across tropical Africa are examined, in conjunction with the newly recognized complexities in the events of systemic inflammation, will this relationship be understood.
AB - The unresolved and complex relationship between nitric oxide and falciparum malaria is reflected in recent genetic and immunohistochemical studies in African children. Different genetic associations, perhaps geographically distinctive, are seen between genetic variants of the inducible nitric oxide gene and various disease manifestations in African populations. The picture might not be complete without considering the emerging roles of carbon monoxide, another endogenous gaseous mediator with similar effects to those of nitric oxide. Only when genetic comparisons from across tropical Africa are examined, in conjunction with the newly recognized complexities in the events of systemic inflammation, will this relationship be understood.
U2 - 10.1016/S1471-4922(03)00147-8
DO - 10.1016/S1471-4922(03)00147-8
M3 - Review article
VL - 19
SP - 335
EP - 337
JO - Trends in Parasitology
JF - Trends in Parasitology
SN - 0169-4758
IS - 8
ER -
