Nitric oxide, malaria and African children

I. Clark, K.A. Rockett, David Burgner

    Research output: Contribution to journalReview article

    26 Citations (Scopus)

    Abstract

    The unresolved and complex relationship between nitric oxide and falciparum malaria is reflected in recent genetic and immunohistochemical studies in African children. Different genetic associations, perhaps geographically distinctive, are seen between genetic variants of the inducible nitric oxide gene and various disease manifestations in African populations. The picture might not be complete without considering the emerging roles of carbon monoxide, another endogenous gaseous mediator with similar effects to those of nitric oxide. Only when genetic comparisons from across tropical Africa are examined, in conjunction with the newly recognized complexities in the events of systemic inflammation, will this relationship be understood.
    Original languageEnglish
    Pages (from-to)335-337
    JournalTrends in Parasitology
    Volume19
    Issue number8
    DOIs
    Publication statusPublished - 2003

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