TY - JOUR
T1 - NIRS and IVUS for characterization of atherosclerosis in patients undergoing coronary angiography
AU - Brugaletta, Salvatore
AU - Garcia-Garcia, Hector M.
AU - Serruys, Patrick W.
AU - De Boer, Sanneke
AU - Ligthart, Jurgen
AU - Gomez-Lara, Josep
AU - Witberg, Karen
AU - Diletti, Roberto
AU - Wykrzykowska, Joanna
AU - Van Geuns, Robert Jan
AU - Schultz, Carl
AU - Regar, Evelyn
AU - Duckers, Henricus J.
AU - Van Mieghem, Nicolas
AU - De Jaegere, Peter
AU - Madden, Sean P.
AU - Muller, James E.
AU - Van Der Steen, Antonius F.W.
AU - Van Der Giessen, Wim J.
AU - Boersma, Eric
PY - 2011/6/1
Y1 - 2011/6/1
N2 - Objectives: The aim of this study was to compare the findings of near-infrared spectroscopy (NIRS), intravascular ultrasound (IVUS) virtual histology (VH), and grayscale IVUS obtained in matched coronary vessel segments of patients undergoing coronary angiography. Background: Intravascular ultrasound VH has been developed to add tissue characterization to the grayscale IVUS assessment of coronary plaques. Near-infrared spectroscopy is a new imaging technique able to identify lipid core-containing coronary plaques (LCP). Methods: We performed NIRS and IVUS-VH pullbacks in a consecutive series of 31 patients with a common region of interest (ROI) between 2 side branches. For each ROI, we analyzed the chemogram blocks by NIRS, plaque area and plaque burden by grayscale IVUS, and tissue types by IVUS-VH. The chemogram block is a summary metric of a 2-mm vertical slice of the chemogram. The value ranges from 0 to 1 according to the presence of lipids and represents the probability of LCP with a color scale from red (low probability) through orange and tan to yellow (high probability). Results: Plaque area (mm 2) increases as percentage VH derived-necrotic core (NC) content (4.6 ± 2.7 vs. 7.4 ± 3.5 vs. 8.6 ± 3.4 vs. 7.9 ± 3.3, grouped in percentage NC quartiles, p < 0.001) and chemogram block probability color bin thresholds increase (4.9 ± 3.8 red, 7.3 ± 3.6 orange, 8.1 ± 3.4 tan, and 8.7 ± 3.4 yellow, p < 0.001). The correlation between the block chemogram detection of lipid core and percentage NC content by VH was weak (r = 0.149). Correction for the presence of calcium does not improve this correlation. Conclusions: Larger plaque area by grayscale IVUS was more often associated with either elevated percentage VH-NC or LCP by NIRS; however, the correlation between the detection of LCP by NIRS and necrotic core by VH is weak.
AB - Objectives: The aim of this study was to compare the findings of near-infrared spectroscopy (NIRS), intravascular ultrasound (IVUS) virtual histology (VH), and grayscale IVUS obtained in matched coronary vessel segments of patients undergoing coronary angiography. Background: Intravascular ultrasound VH has been developed to add tissue characterization to the grayscale IVUS assessment of coronary plaques. Near-infrared spectroscopy is a new imaging technique able to identify lipid core-containing coronary plaques (LCP). Methods: We performed NIRS and IVUS-VH pullbacks in a consecutive series of 31 patients with a common region of interest (ROI) between 2 side branches. For each ROI, we analyzed the chemogram blocks by NIRS, plaque area and plaque burden by grayscale IVUS, and tissue types by IVUS-VH. The chemogram block is a summary metric of a 2-mm vertical slice of the chemogram. The value ranges from 0 to 1 according to the presence of lipids and represents the probability of LCP with a color scale from red (low probability) through orange and tan to yellow (high probability). Results: Plaque area (mm 2) increases as percentage VH derived-necrotic core (NC) content (4.6 ± 2.7 vs. 7.4 ± 3.5 vs. 8.6 ± 3.4 vs. 7.9 ± 3.3, grouped in percentage NC quartiles, p < 0.001) and chemogram block probability color bin thresholds increase (4.9 ± 3.8 red, 7.3 ± 3.6 orange, 8.1 ± 3.4 tan, and 8.7 ± 3.4 yellow, p < 0.001). The correlation between the block chemogram detection of lipid core and percentage NC content by VH was weak (r = 0.149). Correction for the presence of calcium does not improve this correlation. Conclusions: Larger plaque area by grayscale IVUS was more often associated with either elevated percentage VH-NC or LCP by NIRS; however, the correlation between the detection of LCP by NIRS and necrotic core by VH is weak.
KW - intravascular ultrasound
KW - near-infrared spectroscopy
KW - virtual histology
UR - https://www.scopus.com/pages/publications/79958835985
U2 - 10.1016/j.jcmg.2011.03.013
DO - 10.1016/j.jcmg.2011.03.013
M3 - Article
C2 - 21679900
AN - SCOPUS:79958835985
SN - 1936-878X
VL - 4
SP - 647
EP - 655
JO - JACC: Cardiovascular Imaging
JF - JACC: Cardiovascular Imaging
IS - 6
ER -