Night shift work and breast cancer: a pooled analysis of population-based case-control studies with complete work history

Emilie Cordina-Duverger, Florence Menegaux, Alexandru Popa, Sylvia Rabstein, Volker Harth, Beate Pesch, Thomas Bruening, Lin Fritschi, Deborah C. Glass, Jane S. Heyworth, Thomas C. Erren, Gemma Castano-Vinyals, Kyriaki Papantoniou, Ana Espinosa, Manolis Kogevinas, Anne Grundy, John J. Spinelli, Kristan J. Aronson, Pascal Guenel

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Abstract

Night shift work has been suspected to increase breast cancer risk but epidemiological studies have been inconsistent due to heterogeneous assessment of exposure to night work. To overcome this limitation, we pooled data of five population-based case-control studies from Australia, Canada, France, Germany, and Spain into a single harmonized dataset using a common definition of night work including 6093 breast cancer cases and 6933 population controls. The odds ratio for breast cancer in women who ever worked at night for at least 3 h between midnight and 5 a. m. as compared to never night workers was 1.12 (95% CI 1.00-1.25). Among pre-menopausal women, this odds ratio was 1.26 [1.06-1.51], increasing to 1.36 [1.07-1.74] for night shifts >= 10 h, 1.80 [1.20-2.71] for work >= 3 nights/week, and 2.55 [1.03-6.30] for both duration of night work >= 10 years and exposure intensity >= 3 nights/week. Breast cancer risk in pre-menopausal women was higher in current or recent night workers (OR = 1.41 [1.06-1.88]) than in those who had stopped night work more than 2 years ago. Breast cancer in post-menopausal women was not associated with night work whatever the exposure metric. The increase in risk was restricted to ER+ tumors, particularly those who were both ER+ and HER2+. These results support the hypothesis that night shift work increases the risk of breast cancer in pre-menopausal women, particularly those with high intensity and long duration of exposure. Risk difference between pre-and post-menopausal women deserves further scrutiny.

Original languageEnglish
Pages (from-to)369-379
Number of pages11
JournalEuropean Journal of Epidemiology
Volume33
Issue number4
DOIs
Publication statusPublished - Apr 2018

Cite this

Cordina-Duverger, Emilie ; Menegaux, Florence ; Popa, Alexandru ; Rabstein, Sylvia ; Harth, Volker ; Pesch, Beate ; Bruening, Thomas ; Fritschi, Lin ; Glass, Deborah C. ; Heyworth, Jane S. ; Erren, Thomas C. ; Castano-Vinyals, Gemma ; Papantoniou, Kyriaki ; Espinosa, Ana ; Kogevinas, Manolis ; Grundy, Anne ; Spinelli, John J. ; Aronson, Kristan J. ; Guenel, Pascal. / Night shift work and breast cancer : a pooled analysis of population-based case-control studies with complete work history. In: European Journal of Epidemiology. 2018 ; Vol. 33, No. 4. pp. 369-379.
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abstract = "Night shift work has been suspected to increase breast cancer risk but epidemiological studies have been inconsistent due to heterogeneous assessment of exposure to night work. To overcome this limitation, we pooled data of five population-based case-control studies from Australia, Canada, France, Germany, and Spain into a single harmonized dataset using a common definition of night work including 6093 breast cancer cases and 6933 population controls. The odds ratio for breast cancer in women who ever worked at night for at least 3 h between midnight and 5 a. m. as compared to never night workers was 1.12 (95{\%} CI 1.00-1.25). Among pre-menopausal women, this odds ratio was 1.26 [1.06-1.51], increasing to 1.36 [1.07-1.74] for night shifts >= 10 h, 1.80 [1.20-2.71] for work >= 3 nights/week, and 2.55 [1.03-6.30] for both duration of night work >= 10 years and exposure intensity >= 3 nights/week. Breast cancer risk in pre-menopausal women was higher in current or recent night workers (OR = 1.41 [1.06-1.88]) than in those who had stopped night work more than 2 years ago. Breast cancer in post-menopausal women was not associated with night work whatever the exposure metric. The increase in risk was restricted to ER+ tumors, particularly those who were both ER+ and HER2+. These results support the hypothesis that night shift work increases the risk of breast cancer in pre-menopausal women, particularly those with high intensity and long duration of exposure. Risk difference between pre-and post-menopausal women deserves further scrutiny.",
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Cordina-Duverger, E, Menegaux, F, Popa, A, Rabstein, S, Harth, V, Pesch, B, Bruening, T, Fritschi, L, Glass, DC, Heyworth, JS, Erren, TC, Castano-Vinyals, G, Papantoniou, K, Espinosa, A, Kogevinas, M, Grundy, A, Spinelli, JJ, Aronson, KJ & Guenel, P 2018, 'Night shift work and breast cancer: a pooled analysis of population-based case-control studies with complete work history' European Journal of Epidemiology, vol. 33, no. 4, pp. 369-379. https://doi.org/10.1007/s10654-018-0368-x

Night shift work and breast cancer : a pooled analysis of population-based case-control studies with complete work history. / Cordina-Duverger, Emilie; Menegaux, Florence; Popa, Alexandru; Rabstein, Sylvia; Harth, Volker; Pesch, Beate; Bruening, Thomas; Fritschi, Lin; Glass, Deborah C.; Heyworth, Jane S.; Erren, Thomas C.; Castano-Vinyals, Gemma; Papantoniou, Kyriaki; Espinosa, Ana; Kogevinas, Manolis; Grundy, Anne; Spinelli, John J.; Aronson, Kristan J.; Guenel, Pascal.

In: European Journal of Epidemiology, Vol. 33, No. 4, 04.2018, p. 369-379.

Research output: Contribution to journalArticle

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T1 - Night shift work and breast cancer

T2 - a pooled analysis of population-based case-control studies with complete work history

AU - Cordina-Duverger, Emilie

AU - Menegaux, Florence

AU - Popa, Alexandru

AU - Rabstein, Sylvia

AU - Harth, Volker

AU - Pesch, Beate

AU - Bruening, Thomas

AU - Fritschi, Lin

AU - Glass, Deborah C.

AU - Heyworth, Jane S.

AU - Erren, Thomas C.

AU - Castano-Vinyals, Gemma

AU - Papantoniou, Kyriaki

AU - Espinosa, Ana

AU - Kogevinas, Manolis

AU - Grundy, Anne

AU - Spinelli, John J.

AU - Aronson, Kristan J.

AU - Guenel, Pascal

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N2 - Night shift work has been suspected to increase breast cancer risk but epidemiological studies have been inconsistent due to heterogeneous assessment of exposure to night work. To overcome this limitation, we pooled data of five population-based case-control studies from Australia, Canada, France, Germany, and Spain into a single harmonized dataset using a common definition of night work including 6093 breast cancer cases and 6933 population controls. The odds ratio for breast cancer in women who ever worked at night for at least 3 h between midnight and 5 a. m. as compared to never night workers was 1.12 (95% CI 1.00-1.25). Among pre-menopausal women, this odds ratio was 1.26 [1.06-1.51], increasing to 1.36 [1.07-1.74] for night shifts >= 10 h, 1.80 [1.20-2.71] for work >= 3 nights/week, and 2.55 [1.03-6.30] for both duration of night work >= 10 years and exposure intensity >= 3 nights/week. Breast cancer risk in pre-menopausal women was higher in current or recent night workers (OR = 1.41 [1.06-1.88]) than in those who had stopped night work more than 2 years ago. Breast cancer in post-menopausal women was not associated with night work whatever the exposure metric. The increase in risk was restricted to ER+ tumors, particularly those who were both ER+ and HER2+. These results support the hypothesis that night shift work increases the risk of breast cancer in pre-menopausal women, particularly those with high intensity and long duration of exposure. Risk difference between pre-and post-menopausal women deserves further scrutiny.

AB - Night shift work has been suspected to increase breast cancer risk but epidemiological studies have been inconsistent due to heterogeneous assessment of exposure to night work. To overcome this limitation, we pooled data of five population-based case-control studies from Australia, Canada, France, Germany, and Spain into a single harmonized dataset using a common definition of night work including 6093 breast cancer cases and 6933 population controls. The odds ratio for breast cancer in women who ever worked at night for at least 3 h between midnight and 5 a. m. as compared to never night workers was 1.12 (95% CI 1.00-1.25). Among pre-menopausal women, this odds ratio was 1.26 [1.06-1.51], increasing to 1.36 [1.07-1.74] for night shifts >= 10 h, 1.80 [1.20-2.71] for work >= 3 nights/week, and 2.55 [1.03-6.30] for both duration of night work >= 10 years and exposure intensity >= 3 nights/week. Breast cancer risk in pre-menopausal women was higher in current or recent night workers (OR = 1.41 [1.06-1.88]) than in those who had stopped night work more than 2 years ago. Breast cancer in post-menopausal women was not associated with night work whatever the exposure metric. The increase in risk was restricted to ER+ tumors, particularly those who were both ER+ and HER2+. These results support the hypothesis that night shift work increases the risk of breast cancer in pre-menopausal women, particularly those with high intensity and long duration of exposure. Risk difference between pre-and post-menopausal women deserves further scrutiny.

KW - Night shift work

KW - Breast cancer

KW - Pooled analysis

KW - Case-control study

KW - Circadian disruption

KW - NORWEGIAN NURSES

KW - RISK

KW - WOMEN

KW - METAANALYSIS

KW - COHORT

U2 - 10.1007/s10654-018-0368-x

DO - 10.1007/s10654-018-0368-x

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JO - European Journal of Epidemiology

JF - European Journal of Epidemiology

SN - 0393-2990

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ER -