Nigerapyrones A-H, α-pyrone derivatives from the marine mangrove-derived endophytic fungus Aspergillus niger MA-132

Dong Liu, Xiao Ming Li, Li Meng, Chun Shun Li, Shu Shan Gao, Zhuo Shang, Peter Proksch, Cai Guo Huang, Bin Gui Wang

Research output: Contribution to journalArticlepeer-review

96 Citations (Scopus)

Abstract

Eight new α-pyrone derivatives, namely, nigerapyrones A-E (1-5) and nigerapyrones F-H (8-10), along with two known congeners, asnipyrones B (6) and A (7), were isolated from Aspergillus niger MA-132, an endophytic fungus obtained from the fresh tissue of the marine mangrove plant Avicennia marina. The structures of these compounds were elucidated on the basis of spectroscopic analysis. The undescribed geometries of the trisubstituted double bonds (C-9 and C-11) for asnipyrone B (6) have now been explicitly determined, while the incorrect placement of the methyl group at C-5 of asnipyrone A (7) has now been revised at C-3. The cytotoxic activities of the isolated α-pyrone derivatives against eight tumor cell lines as well as antimicrobial activities against two bacteria and four plant-pathogenic fungi of these compounds were evaluated. Compounds 2, 4, 5, and 7 showed weak cytotoxicity against some of the tested tumor cell lines.

Original languageEnglish
Pages (from-to)1787-1791
Number of pages5
JournalJournal of Natural Products
Volume74
Issue number8
DOIs
Publication statusPublished - 26 Aug 2011
Externally publishedYes

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