Nickel Phosphite/Phosphine-Catalyzed C-S Cross-Coupling of Aryl Chlorides and Thiols

Kieran D. Jones; Dennis J. Power; Donald Bierer; Kersten M. Gericke; Scott G. Stewart

doi:10.1021/acs.orglett.7b03560

Nickel Phosphite/Phosphine-Catalyzed C-S Cross-Coupling of Aryl Chlorides and Thiols

Kieran D. Jones, Dennis J. Power, Donald Bierer, Kersten M. Gericke, Scott G. Stewart

School of Molecular Sciences

Research output: Contribution to journal › Article › peer-review

105 Citations (Scopus)

Abstract

A method for the coupling of aryl chlorides and thiophenols using an air-stable nickel(0) catalyst is described. This thioetherification procedure can be effectively applied to a range of electronically diverse aryl/heteroaryl chlorides without more expensive metal catalysts such as palladium, iridium, or ruthenium. This investigation also illustrates both, a variety of thiol coupling partners and, in certain cases, the use of Cs₂CO₃.

Original language	English
Pages (from-to)	208-211
Number of pages	4
Journal	Organic Letters
Volume	20
Issue number	1
DOIs	https://doi.org/10.1021/acs.orglett.7b03560
Publication status	Published - 5 Jan 2018

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AU - Stewart, Scott G.

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AB - A method for the coupling of aryl chlorides and thiophenols using an air-stable nickel(0) catalyst is described. This thioetherification procedure can be effectively applied to a range of electronically diverse aryl/heteroaryl chlorides without more expensive metal catalysts such as palladium, iridium, or ruthenium. This investigation also illustrates both, a variety of thiol coupling partners and, in certain cases, the use of Cs2CO3.

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Nickel Phosphite/Phosphine-Catalyzed C-S Cross-Coupling of Aryl Chlorides and Thiols

Abstract

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