Next generation sequencing and its application in deciphering head and neck cancer

Maryam Jessri, Camile S. Farah

Research output: Contribution to journalReview article

19 Citations (Scopus)

Abstract

Head and neck squamous cell carcinoma (HNSCC) are a group of heterogeneous tumours mainly attributable to tobacco use, alcohol consumption and infection with human papillomavirus. Based on the stage of cancer at the time of diagnosis, patients are managed by surgery, radiotherapy, chemotherapy or a combination of these. Early diagnosis usually improves patient prognosis. Since their first commercial application in 2005, next generation sequencing (NGS) platforms are rapidly changing the face of basic science laboratories; however prior to progressing to clinical applications, clinicians should carefully examine currently available data and guidelines for technical and ethical matters concerning NGS. In this review, we compare various commercially available NGS platforms, with special consideration given to their clinical application in the management of HNSCC.

Original languageEnglish
Pages (from-to)247-253
Number of pages7
JournalOral Oncology
Volume50
Issue number4
DOIs
Publication statusPublished - 2014
Externally publishedYes

Fingerprint Dive into the research topics of 'Next generation sequencing and its application in deciphering head and neck cancer'. Together they form a unique fingerprint.

  • Cite this