TY - JOUR
T1 - Next generation sequencing and its application in deciphering head and neck cancer
AU - Jessri, Maryam
AU - Farah, Camile S.
PY - 2014
Y1 - 2014
N2 - Head and neck squamous cell carcinoma (HNSCC) are a group of heterogeneous tumours mainly attributable to tobacco use, alcohol consumption and infection with human papillomavirus. Based on the stage of cancer at the time of diagnosis, patients are managed by surgery, radiotherapy, chemotherapy or a combination of these. Early diagnosis usually improves patient prognosis. Since their first commercial application in 2005, next generation sequencing (NGS) platforms are rapidly changing the face of basic science laboratories; however prior to progressing to clinical applications, clinicians should carefully examine currently available data and guidelines for technical and ethical matters concerning NGS. In this review, we compare various commercially available NGS platforms, with special consideration given to their clinical application in the management of HNSCC.
AB - Head and neck squamous cell carcinoma (HNSCC) are a group of heterogeneous tumours mainly attributable to tobacco use, alcohol consumption and infection with human papillomavirus. Based on the stage of cancer at the time of diagnosis, patients are managed by surgery, radiotherapy, chemotherapy or a combination of these. Early diagnosis usually improves patient prognosis. Since their first commercial application in 2005, next generation sequencing (NGS) platforms are rapidly changing the face of basic science laboratories; however prior to progressing to clinical applications, clinicians should carefully examine currently available data and guidelines for technical and ethical matters concerning NGS. In this review, we compare various commercially available NGS platforms, with special consideration given to their clinical application in the management of HNSCC.
KW - Head and neck cancer
KW - Next generation sequencing
KW - Oral cancer
KW - Personalized cancer therapy
KW - RNA-seq
UR - http://www.scopus.com/inward/record.url?scp=84895495953&partnerID=8YFLogxK
U2 - 10.1016/j.oraloncology.2013.12.017
DO - 10.1016/j.oraloncology.2013.12.017
M3 - Review article
C2 - 24440145
AN - SCOPUS:84895495953
SN - 1368-8375
VL - 50
SP - 247
EP - 253
JO - Oral Oncology
JF - Oral Oncology
IS - 4
ER -