New roles of cyclin D1

Research output: Contribution to journalReview articlepeer-review

171 Citations (Scopus)


Cyclins encode regulatory subunits of holoenzymes that phosphorylate a variety of cellular substrates. Although the classic role of cyclins in cell cycle progression and tumorigenesis has been well characterized, new functions have been identified, including the induction of cellular migration and invasion, enhancement of angiogenesis, inhibition of mitochondrial metabolism, regulation of transcription factor signaling via a DNA-bound form, the induction of chromosomal instability, enhancement of DNA damage sensing and DNA damage repair, and feedback governing expression of the noncoding genome. This review describes the mechanisms of these new functions of cyclin D1.

Original languageEnglish
Pages (from-to)3-9
Number of pages7
JournalAmerican Journal of Pathology
Issue number1
Publication statusPublished - Jul 2013
Externally publishedYes


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