New Organo Gold Complexes of N-Heterocyclic Carbenes as Potential Anti-Cancer Agents

Hawraa Al-Buthabhak

Research output: ThesisDoctoral Thesis

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Abstract

This thesis reports the first synthesis and characterisation of Au complexes of form (NHC)Au(SCOR), (A2Im)AuCl, [(Tz2Im)AuCl3], and [(ArBr2Im)2Au]Br(SCOR = thiocarboxylate ligand, NHC = N-heterocyclic carbene, A2Im = diallenylimidazolin-2-ylidene, Tz2Im = di(triazolyl)imidazolin-2-ylidene, ArBr2Im = bis(3,5-dibromophenyl)imidazolin-2-ylidene. The SCOR- ligand was more liable than NHC ligand. Treatment of [(Tz2NHC)AuCl3] with AgNO3 led to [k3-(Tz2NHC)AuCl](NO3)2 in which Tz2HNC binds Au via two triazolyl N atoms and the NHC carbon. Allenyl-imidazolium salts and (A2Im)ML complexes (M = Ag, Au; L = Cl, A2Im, MeCN) were sensitive. The new AuI-NHC complexes inhibited the growth of ovarian cancer (OVCAR-8) cells at low micromolar concentrations.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Baker, Murray, Supervisor
  • Low, Paul, Supervisor
  • Ferro, Vito, Supervisor
Award date18 Jun 2021
DOIs
Publication statusUnpublished - 2021

Embargo information

  • Embargoed from 21/06/2021 to 26/05/2022. Made publicly available on 26/05/2022.

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