New Insights on COX-2 in Chronic Inflammation Driving Breast Cancer Growth and Metastasis

H.J. Hugo, Christobel Saunders, R.G. Ramsay, E.W. Thompson

    Research output: Contribution to journalReview article

    52 Citations (Scopus)

    Abstract

    © 2015, Springer Science+Business Media New York. The medicinal use of aspirin stretches back to ancient times, before it was manufactured in its pure form in the late 19th century. Its accepted mechanistic target, cyclooxygenase (COX), was discovered in the 1970s and since this landmark discovery, the therapeutic application of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) has increased dramatically. The most significant benefits of NSAIDs are in conditions involving chronic inflammation (CI). Given the recognized role of CI in cancer development, the use of long-term NSAID treatment in the prevention of cancer is an enticing possibility. COX-2 is a key driver of CI, and here we review COX-2 expression as a predictor of survival in various cancer types, including breast. Obesity and post-partum involution are natural inflammatory states that are associated with increased breast cancer risk. We outline the COX-2 mediated mechanisms contributing to the growth of cancers. We dissect the cellular mechanism of epithelial-mesenchymal transition (EMT) and how COX-2 may induce this to facilitate tumor progression. Finally we examine the potential regulation of COX-2 by c-Myb, and the possible interplay between c-Myb/COX-2 in proliferation, and hypoxia inducible factor-1 alpha (HIF1α)/COX-2 in invasive pathways in breast cancer.
    Original languageEnglish
    Pages (from-to)109-119
    JournalJournal of Mammary Gland Biology and Neoplasia
    Volume20
    Issue number3-4
    Early online date21 Jul 2015
    DOIs
    Publication statusPublished - Dec 2015

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